| pubmed-article:8132209 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0013621 | lld:lifeskim |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0237868 | lld:lifeskim |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0036679 | lld:lifeskim |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:8132209 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:8132209 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8132209 | pubmed:dateCreated | 1994-4-18 | lld:pubmed |
| pubmed-article:8132209 | pubmed:abstractText | Participation of transmembrane (TM) and glycosyl-phosphatidylinositol (GPI) anchored H-2Db molecules in antigen presentation and thymic selection events was investigated using transgenic mice. Both GPI-Db and TM-Db can efficiently present H-Y antigen, influenza and lymphocytic choriomeningitis virus (LCMV) peptides to primed cytotoxic, H-2Db-restricted T cells. Transgenic mice expressing GPI-Db, although unable to reject TM-Db skin grafts, nevertheless generate secondary CTL responses which can lyse TM-Db-bearing targets, indicating that GPI-Db mice fail to delete all TM-Db-reactive T cells. Furthermore, double-transgenic mice bearing GPI-Db and a T-cell receptor (TcR) for H-2Db+LCMV do not positively select receptor positive, CD8+CD4- T cells. This paradoxical behaviour of GPI-Db molecules suggests that the structural requirements for antigen presentation and thymic selection by class I molecules are different and may explain why GPI-linked class I molecules, such as Qa-2, do not appear to function as restriction elements in vivo. | lld:pubmed |
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| pubmed-article:8132209 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8132209 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8132209 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8132209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8132209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8132209 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8132209 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8132209 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:8132209 | pubmed:author | pubmed-author:SimpsonEE | lld:pubmed |
| pubmed-article:8132209 | pubmed:author | pubmed-author:ChandlerPP | lld:pubmed |
| pubmed-article:8132209 | pubmed:author | pubmed-author:TomlinsonPP | lld:pubmed |
| pubmed-article:8132209 | pubmed:author | pubmed-author:RobinsonP JPJ | lld:pubmed |
| pubmed-article:8132209 | pubmed:author | pubmed-author:MellonMM | lld:pubmed |
| pubmed-article:8132209 | pubmed:author | pubmed-author:MillrainM MMM | lld:pubmed |
| pubmed-article:8132209 | pubmed:author | pubmed-author:BrändleDD | lld:pubmed |
| pubmed-article:8132209 | pubmed:author | pubmed-author:AntoniouJJ | lld:pubmed |
| pubmed-article:8132209 | pubmed:author | pubmed-author:PircherH PHP | lld:pubmed |
| pubmed-article:8132209 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8132209 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:8132209 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8132209 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8132209 | pubmed:pagination | 132-6 | lld:pubmed |
| pubmed-article:8132209 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8132209 | pubmed:meshHeading | pubmed-meshheading:8132209-... | lld:pubmed |
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| pubmed-article:8132209 | pubmed:meshHeading | pubmed-meshheading:8132209-... | lld:pubmed |
| pubmed-article:8132209 | pubmed:meshHeading | pubmed-meshheading:8132209-... | lld:pubmed |
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| pubmed-article:8132209 | pubmed:meshHeading | pubmed-meshheading:8132209-... | lld:pubmed |
| pubmed-article:8132209 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8132209 | pubmed:articleTitle | Separation of thymic education from antigen presenting functions of major histocompatibility complex class I molecules. | lld:pubmed |
| pubmed-article:8132209 | pubmed:affiliation | Clinical Research Centre, Harrow, Middlesex, U.K. | lld:pubmed |
| pubmed-article:8132209 | pubmed:publicationType | Journal Article | lld:pubmed |
