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pubmed-article:8128247pubmed:abstractTextIn wild-type Drosophila, the period protein (PER) is found in nuclei of the eyes and brain, and PER immunoreactivity oscillates with a circadian rhythm. The studies described here indicate that the nuclear localization of PER is blocked by timeless (tim), a second chromosome mutation that, like per null mutations, abolishes circadian rhythms. PER fusion proteins without a conserved domain (PAS) and some flanking sequences are nuclear in tim mutants. This suggests that a segment of PER inhibits nuclear localization in tim mutants. The tim gene may have a role in establishing rhythms of PER abundance and nuclear localization in wild-type flies.lld:pubmed
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pubmed-article:8128247pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:8128247pubmed:articleTitleBlock in nuclear localization of period protein by a second clock mutation, timeless.lld:pubmed
pubmed-article:8128247pubmed:affiliationHoward Hughes Medical Institute, National Science Foundation Science and Technology Center for Biological Timing, and Laboratory of Genetics, Rockefeller University, New York, NY 10021.lld:pubmed
pubmed-article:8128247pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8128247pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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