| pubmed-article:8120139 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8120139 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:8120139 | lifeskim:mentions | umls-concept:C0026896 | lld:lifeskim |
| pubmed-article:8120139 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:8120139 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8120139 | lifeskim:mentions | umls-concept:C0001041 | lld:lifeskim |
| pubmed-article:8120139 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8120139 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:8120139 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8120139 | pubmed:dateCreated | 1994-4-1 | lld:pubmed |
| pubmed-article:8120139 | pubmed:abstractText | Patients with myasthenia gravis have a high prevalence of acetylcholine receptor-specific T lymphocytes in the peripheral blood. Our earlier study shows that these T lymphocytes are stimulated to secrete interferon (IFN)-gamma and interleukin (IL)-2 in response to the autoantigen. Such stimulated T cells may be subdivided into different subsets according to the pattern of cytokine production. In the present study we have investigated the subpopulations of cells by analyzing their IL-4, IFN-gamma and IL-2 secretion pattern. Autoantigen-stimulated IL-4 secretion was found in 55% of the patients, IFN-gamma secretion in 86% and IL-2 secretion in 72%. T lymphocytes from all patients who responded with increased IL-2 secretion also showed increased IFN-gamma secretion. Stimulated IL-4 secretion was detected both in the presence and absence of stimulated IFN-gamma secretion. Depletion of monocytes/macrophages from peripheral blood mononuclear cell preparation and treatment of the cells with a mouse anti-human HLA-DR antibody abolished the secretion of IFN-gamma and IL-4. There were positive correlations between the numbers of IFN-gamma- and IL-2-secreting T cells and the numbers of B cells secreting antibodies against the acetylcholine receptor. Our results show that acetylcholine receptor-stimulated T lymphocytes secrete IL-4, IFN-gamma and/or IL-2. This T cell response is major histocompatibility complex (MHC) class II-restricted and monocyte/macrophage-dependent. Our study indicates that both Th1/Th2 or Th0 subpopulations of the T lymphocytes are involved in the autoimmune response in myasthenia gravis. | lld:pubmed |
| pubmed-article:8120139 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8120139 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8120139 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8120139 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8120139 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8120139 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8120139 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8120139 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8120139 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8120139 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8120139 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:8120139 | pubmed:author | pubmed-author:PirskanenRR | lld:pubmed |
| pubmed-article:8120139 | pubmed:author | pubmed-author:LefvertA KAK | lld:pubmed |
| pubmed-article:8120139 | pubmed:author | pubmed-author:YeMM | lld:pubmed |
| pubmed-article:8120139 | pubmed:author | pubmed-author:AhlbergRR | lld:pubmed |
| pubmed-article:8120139 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8120139 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:8120139 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8120139 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8120139 | pubmed:pagination | 177-86 | lld:pubmed |
| pubmed-article:8120139 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8120139 | pubmed:meshHeading | pubmed-meshheading:8120139-... | lld:pubmed |
| pubmed-article:8120139 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8120139 | pubmed:articleTitle | Acetylcholine receptor-reactive T cells in myasthenia gravis: evidence for the involvement of different subpopulations of T helper cells. | lld:pubmed |
| pubmed-article:8120139 | pubmed:affiliation | Immunological Research Laboratory, Karolinska Hospital, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:8120139 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8120139 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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