| pubmed-article:8105361 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8105361 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:8105361 | lifeskim:mentions | umls-concept:C0004589 | lld:lifeskim |
| pubmed-article:8105361 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8105361 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8105361 | lifeskim:mentions | umls-concept:C0205151 | lld:lifeskim |
| pubmed-article:8105361 | lifeskim:mentions | umls-concept:C0032521 | lld:lifeskim |
| pubmed-article:8105361 | lifeskim:mentions | umls-concept:C0301644 | lld:lifeskim |
| pubmed-article:8105361 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8105361 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8105361 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8105361 | pubmed:dateCreated | 1993-11-9 | lld:pubmed |
| pubmed-article:8105361 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8105361 | pubmed:abstractText | Bacillus anthracis produces a gamma-linked poly-D-glutamic acid capsule that is essential for virulence. A 6.2 kb fragment of B. anthracis DNA (cap), when present in Escherichia coli, produces a capsular polymer that is immunologically identical to that produced by B. anthracis. By immunodiffusion analysis of E. coli strains carrying varying portions of the cap region, we identified a novel gene (dep) responsible for degradation of the capsular polymer of B. anthracis. The simultaneous presence of the cap region and the dep gene caused production of low-molecular-weight, degraded capsular polymer both in E. coli and in B. anthracis, whereas the cap region alone caused production of a high-molecular-weight capsule. The dep gene mapped immediately downstream of the cap region within a 1.8 kb fragment and was transcribed in the same direction. This fragment was sequenced and a 1401 bp open reading frame (ORF) was found that is predicted to encode a peptide with molecular weight of 51,460. By in vitro transcription-translation analysis, this ORF was shown to be the dep gene product. The deduced amino acid sequence of the dep product has sequence similarity to E. coli and mammalian gamma-glutamyltranspeptidase (GGT). However, the Dep protein did not have GGT activity. The Dep protein appears to be an enzyme that catalyses the hydrolysis of the poly-D-glutamic acid capsule. Although the biological functions of the dep gene are unknown, it is possible that low-molecular-weight, diffusible polyglutamates produced through the action of the dep gene may act to inhibit host defence mechanisms. | lld:pubmed |
| pubmed-article:8105361 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8105361 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8105361 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8105361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8105361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8105361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8105361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8105361 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8105361 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8105361 | pubmed:issn | 0950-382X | lld:pubmed |
| pubmed-article:8105361 | pubmed:author | pubmed-author:YoshikawaMM | lld:pubmed |
| pubmed-article:8105361 | pubmed:author | pubmed-author:SugimotoCC | lld:pubmed |
| pubmed-article:8105361 | pubmed:author | pubmed-author:MakinoSS | lld:pubmed |
| pubmed-article:8105361 | pubmed:author | pubmed-author:UchidaII | lld:pubmed |
| pubmed-article:8105361 | pubmed:author | pubmed-author:TerakadoNN | lld:pubmed |
| pubmed-article:8105361 | pubmed:author | pubmed-author:SasakawaCC | lld:pubmed |
| pubmed-article:8105361 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8105361 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:8105361 | pubmed:geneSymbol | dep | lld:pubmed |
| pubmed-article:8105361 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8105361 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8105361 | pubmed:pagination | 487-96 | lld:pubmed |
| pubmed-article:8105361 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8105361 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8105361 | pubmed:articleTitle | Identification of a novel gene, dep, associated with depolymerization of the capsular polymer in Bacillus anthracis. | lld:pubmed |
| pubmed-article:8105361 | pubmed:affiliation | National Institute of Animal Health, Tsukuba Science City, Ibaraki, Japan. | lld:pubmed |
| pubmed-article:8105361 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8105361 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8105361 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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