| pubmed-article:8105099 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C0678133 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C2828389 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C0205410 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:8105099 | lifeskim:mentions | umls-concept:C0056476 | lld:lifeskim |
| pubmed-article:8105099 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:8105099 | pubmed:dateCreated | 1993-10-28 | lld:pubmed |
| pubmed-article:8105099 | pubmed:abstractText | Paclitaxel (Taxol) is the first of a new class of cytotoxic agents with activity against tumors resistant to other drugs. For clinical use, paclitaxel is currently formulated in a vehicle of 50% ethanol and 50% polyethoxylated surfactant Cremophor EL (Cremophor). We have previously shown that Cremophor will block the P-glycoprotein drug efflux pump responsible for the multidrug-resistant phenotype. Overexpression of P-glycoprotein is one mechanism of in vitro resistance to a number of currently used cytotoxic agents including paclitaxel. | lld:pubmed |
| pubmed-article:8105099 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8105099 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8105099 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8105099 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8105099 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8105099 | pubmed:issn | 0027-8874 | lld:pubmed |
| pubmed-article:8105099 | pubmed:author | pubmed-author:BishopJJ | lld:pubmed |
| pubmed-article:8105099 | pubmed:author | pubmed-author:WoodcockDD | lld:pubmed |
| pubmed-article:8105099 | pubmed:author | pubmed-author:WebsterLL | lld:pubmed |
| pubmed-article:8105099 | pubmed:author | pubmed-author:MortonCC | lld:pubmed |
| pubmed-article:8105099 | pubmed:author | pubmed-author:MillwardMM | lld:pubmed |
| pubmed-article:8105099 | pubmed:author | pubmed-author:LinsenmeyerMM | lld:pubmed |
| pubmed-article:8105099 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8105099 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:8105099 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:8105099 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8105099 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8105099 | pubmed:pagination | 1685-90 | lld:pubmed |
| pubmed-article:8105099 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8105099 | pubmed:meshHeading | pubmed-meshheading:8105099-... | lld:pubmed |
| pubmed-article:8105099 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8105099 | pubmed:articleTitle | Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype. | lld:pubmed |
| pubmed-article:8105099 | pubmed:affiliation | Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia. | lld:pubmed |
| pubmed-article:8105099 | pubmed:publicationType | Journal Article | lld:pubmed |
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