| pubmed-article:8103717 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8103717 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:8103717 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:8103717 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:8103717 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8103717 | lifeskim:mentions | umls-concept:C0024348 | lld:lifeskim |
| pubmed-article:8103717 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8103717 | pubmed:dateCreated | 1993-10-13 | lld:pubmed |
| pubmed-article:8103717 | pubmed:abstractText | Individuals infected with HIV have elevated numbers of total and activated CD8+ lymphocytes in peripheral blood. CD8+ lymphocytes from HIV-infected individuals have been shown to mediate non-human histocompatibility-linked antigen (HLA)-restricted suppression of viral replication, HLA-restricted killing of cells expressing HIV antigens, and killing of uninfected lymphocytes. We studied CD8+ T lymphocytes that lysed autologous CD4+ lymphocytes. heterologous CD4+ lymphocytes from HIV-infected individuals and uninfected CD4+ lymphocytes. Killing in all cases required T cell receptor (TCR)-mediated recognition or triggering. However, these CD8+ cytotoxic T lymphocytes (CTL) killed HLA class I mismatched CD4+ lymphocytes and CD4+ lymphocytes treated with a MoAb against HLA-A, B and C antigens (PA2.6) which blocks HLA class I-restricted killing. HLA class II-negative CD4+ T lymphoma cells (CEM.NKR) were also killed by anti-CD3 inhibited CTL. Stimulation of peripheral blood lymphocytes (PBL) from HIV-infected individuals, but not uninfected controls, with concanavalin A (Con A) and IL-2, induced non-HLA-restricted TCR alpha beta+, CD8+ CTL which lysed CD4+ lymphocytes. Activation of CD4+ lymphocytes increased their susceptibility to CD8+ CTL-mediated lysis. In HIV infection, a population of non-HLA-restricted CTL which lyse activated CD4+ lymphocytes is expanded. The expansion of CTL with unusual characteristics is interesting, because the stimulus for this expansion is unknown. CTL which recognize activated CD4+ cells could play a role in immune regulation and the pathogenesis of AIDS. | lld:pubmed |
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| pubmed-article:8103717 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8103717 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8103717 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8103717 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8103717 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8103717 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:8103717 | pubmed:author | pubmed-author:RosenthalK... | lld:pubmed |
| pubmed-article:8103717 | pubmed:author | pubmed-author:GrantM DMD | lld:pubmed |
| pubmed-article:8103717 | pubmed:author | pubmed-author:SmaillF MFM | lld:pubmed |
| pubmed-article:8103717 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8103717 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8103717 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8103717 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8103717 | pubmed:pagination | 356-62 | lld:pubmed |
| pubmed-article:8103717 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8103717 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8103717 | pubmed:articleTitle | Lysis of CD4+ lymphocytes by non-HLA-restricted cytotoxic T lymphocytes from HIV-infected individuals. | lld:pubmed |
| pubmed-article:8103717 | pubmed:affiliation | Department of Pathology, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada. | lld:pubmed |
| pubmed-article:8103717 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8103717 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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