| pubmed-article:8100746 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C1155003 | lld:lifeskim |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C0205420 | lld:lifeskim |
| pubmed-article:8100746 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:8100746 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8100746 | pubmed:dateCreated | 1993-8-12 | lld:pubmed |
| pubmed-article:8100746 | pubmed:abstractText | In clinically quiescent SLE hypergammaglobulinaemia, presence of autoantibodies, and increased soluble IL-2 receptors (sIL-2R) have been reported, suggesting persistent B as well as T cell activation. In contrast, the primary immune response to test antigens is markedly decreased. To analyse these phenomena at a cellular level, we undertook a cross-sectional study on 13 non-active SLE patients and 15 controls. We determined the composition of lymphocyte subsets with special attention to activation markers (CD25, HLA-DR, CD38) and the presence of naive T cells (CD45RO-), and related those findings to serological parameters. In non-active SLE patients the expression of activation markers on B cells and T cells was higher than in normal controls (P < or = 0.02), but was not interrelated. Percentages of activated B cells in SLE were related to levels of total IgG (P < 0.02) and IgM (P < 0.02) but not to anti-dsDNA, suggesting a disordered immune system also in clinically quiescent SLE. Numbers of CD4+ cells (P < 0.001) and CD4+CD45RO- cells (P < 0.05) were decreased. The latter finding might explain the anergy to primary test antigens in clinically quiescent SLE. | lld:pubmed |
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| pubmed-article:8100746 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8100746 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8100746 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8100746 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8100746 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8100746 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:8100746 | pubmed:author | pubmed-author:KallenbergC... | lld:pubmed |
| pubmed-article:8100746 | pubmed:author | pubmed-author:LimburgP CPC | lld:pubmed |
| pubmed-article:8100746 | pubmed:author | pubmed-author:SpronkP EPE | lld:pubmed |
| pubmed-article:8100746 | pubmed:author | pubmed-author:vd GunB TBT | lld:pubmed |
| pubmed-article:8100746 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8100746 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8100746 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8100746 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8100746 | pubmed:pagination | 39-44 | lld:pubmed |
| pubmed-article:8100746 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8100746 | pubmed:meshHeading | pubmed-meshheading:8100746-... | lld:pubmed |
| pubmed-article:8100746 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8100746 | pubmed:articleTitle | B cell activation in clinically quiescent systemic lupus erythematosus (SLE) is related to immunoglobulin levels, but not to levels of anti-dsDNA, nor to concurrent T cell activation. | lld:pubmed |
| pubmed-article:8100746 | pubmed:affiliation | Department of Internal Medicine, University Hospital Groningen, The Netherlands. | lld:pubmed |
| pubmed-article:8100746 | pubmed:publicationType | Journal Article | lld:pubmed |
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