| pubmed-article:8096780 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C1413682 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C1705191 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C1552923 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C1552858 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C1551341 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C1552924 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C0056792 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C0205155 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C0047123 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C0049860 | lld:lifeskim |
| pubmed-article:8096780 | lifeskim:mentions | umls-concept:C0813872 | lld:lifeskim |
| pubmed-article:8096780 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8096780 | pubmed:dateCreated | 1993-5-13 | lld:pubmed |
| pubmed-article:8096780 | pubmed:abstractText | 1. The regional binding of [3H]-(+)-5-methyl-10,11-dihydro-5H-dibenzo (a,d)cyclohepten-5,10-imine maleate ([3H]-(+)-MK 801) to sections of rat brain was measured by an in vitro quantitative autoradiographic technique. A heterogeneous distribution of binding sites was observed. 2. High values of binding were detected in the hippocampal formation and cerebral cortex, while very low binding was found in cerebellum. [3H]-(+)-MK 801 binding was not detectable in white matter tracts or in the brain stem. 3. [3H]-(+)-MK 801 binding was inhibited by increasing concentrations of both 7-chlorokynurenate (1-1000 microM) and ((+)-2-carboxypiperazine-4-yl)propyl-1-phosphonic acid (CPP) (0.1-100 microM). High concentrations of both drugs were able to inhibit completely specific [3H]-(+)-MK 801 binding. 4. IC50 values calculated for both 7-chlorokynurenate and CPP-induced [3H]-(+)-MK 801 binding inhibition were similar in all brain regions analyzed. 5. The inhibitory action of 7-chlorokynurenate and that of CPP on [3H]-(+)-MK 801 binding were reversed by addition of glycine and glutamate respectively. 6. It is concluded that activation of glycine and N-methyl-D-aspartate (NMDA) receptors is obligatory for the binding of [3H]-(+)-MK 801 to occur in all of the brain regions examined in the present study. Furthermore, on the basis of the similar regional sensitivities of [3H]-(+)-MK 801 binding to the inhibitory action of 7-chlorokynurenate and CPP, a single pharmacological classification of the NMDA receptor complex in brain is suggested. The cerebellum was not included in the study due to the very low level of [3H]-(+)-MK 801 binding detected under the experimental conditions used. | lld:pubmed |
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| pubmed-article:8096780 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8096780 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8096780 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8096780 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8096780 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:8096780 | pubmed:author | pubmed-author:BoweryN GNG | lld:pubmed |
| pubmed-article:8096780 | pubmed:author | pubmed-author:TacconeWW | lld:pubmed |
| pubmed-article:8096780 | pubmed:author | pubmed-author:RattiEE | lld:pubmed |
| pubmed-article:8096780 | pubmed:author | pubmed-author:GaviraghiGG | lld:pubmed |
| pubmed-article:8096780 | pubmed:author | pubmed-author:MarienM RMR | lld:pubmed |
| pubmed-article:8096780 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8096780 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:8096780 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8096780 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8096780 | pubmed:pagination | 577-82 | lld:pubmed |
| pubmed-article:8096780 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8096780 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8096780 | pubmed:articleTitle | Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis. | lld:pubmed |
| pubmed-article:8096780 | pubmed:affiliation | Glaxo Research Laboratories, Verona, Italy. | lld:pubmed |
| pubmed-article:8096780 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8096780 | pubmed:publicationType | In Vitro | lld:pubmed |
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