| pubmed-article:8096360 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8096360 | lifeskim:mentions | umls-concept:C1140680 | lld:lifeskim |
| pubmed-article:8096360 | lifeskim:mentions | umls-concept:C1516196 | lld:lifeskim |
| pubmed-article:8096360 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:8096360 | lifeskim:mentions | umls-concept:C0796350 | lld:lifeskim |
| pubmed-article:8096360 | lifeskim:mentions | umls-concept:C1520755 | lld:lifeskim |
| pubmed-article:8096360 | lifeskim:mentions | umls-concept:C0023745 | lld:lifeskim |
| pubmed-article:8096360 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8096360 | lifeskim:mentions | umls-concept:C2745888 | lld:lifeskim |
| pubmed-article:8096360 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8096360 | pubmed:dateCreated | 1993-4-23 | lld:pubmed |
| pubmed-article:8096360 | pubmed:abstractText | Genes on chromosomes 17q and 18q have been shown to code for putative tumor suppressors. By a combination of allele-loss studies on sporadic ovarian carcinomas and linkage analysis on a breast/ovarian cancer family, we have investigated the involvement of such genes in these diseases. Allele loss occurred in sporadic tumors from both chromosome 17p, in 18/26 (69%) cases, and chromosome 17q, in 15/22 (68%) cases. In the three familial tumors studied, allele loss also occurred on chromosome 17 (in 2/3 cases for 17p markers and in 2/2 cases for a 17q allele). Allele loss on chromosome 18q, at the DCC (deleted in colorectal carcinomas) locus, was not as common (6/16 cases [38%]) in sporadic ovarian tumors but had occurred in all three familial tumors. The results of linkage analysis on the breast/ovarian cancer family suggested linkage between the disease locus and 17q markers, with a maximum lod score of 1.507 obtained with Mfd188 (D17S579) polymorphism at 5% recombination. The maximum lod score for DCC was 0.323 at 0.1% recombination. In this family our results are consistent with a predisposing gene for breast/ovarian cancer being located at chromosome 17q21. | lld:pubmed |
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| pubmed-article:8096360 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8096360 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8096360 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8096360 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8096360 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8096360 | pubmed:issn | 0002-9297 | lld:pubmed |
| pubmed-article:8096360 | pubmed:author | pubmed-author:HallMM | lld:pubmed |
| pubmed-article:8096360 | pubmed:author | pubmed-author:JohnstonAA | lld:pubmed |
| pubmed-article:8096360 | pubmed:author | pubmed-author:ParkinDD | lld:pubmed |
| pubmed-article:8096360 | pubmed:author | pubmed-author:CruickshankDD | lld:pubmed |
| pubmed-article:8096360 | pubmed:author | pubmed-author:KitchenerHH | lld:pubmed |
| pubmed-article:8096360 | pubmed:author | pubmed-author:KellyK FKF | lld:pubmed |
| pubmed-article:8096360 | pubmed:author | pubmed-author:HaitesNN | lld:pubmed |
| pubmed-article:8096360 | pubmed:author | pubmed-author:MilnerB JBJ | lld:pubmed |
| pubmed-article:8096360 | pubmed:author | pubmed-author:AllanL ALA | lld:pubmed |
| pubmed-article:8096360 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8096360 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:8096360 | pubmed:geneSymbol | DCC | lld:pubmed |
| pubmed-article:8096360 | pubmed:geneSymbol | GH | lld:pubmed |
| pubmed-article:8096360 | pubmed:geneSymbol | 42D6 | lld:pubmed |
| pubmed-article:8096360 | pubmed:geneSymbol | CMM86 | lld:pubmed |
| pubmed-article:8096360 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8096360 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8096360 | pubmed:pagination | 761-6 | lld:pubmed |
| pubmed-article:8096360 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8096360 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8096360 | pubmed:articleTitle | Linkage studies with 17q and 18q markers in a breast/ovarian cancer family. | lld:pubmed |
| pubmed-article:8096360 | pubmed:affiliation | Department of Molecular and Cell Biology (Medical Genetics), University of Aberdeen, Scotland. | lld:pubmed |
| pubmed-article:8096360 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8096360 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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