| pubmed-article:8095393 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8095393 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8095393 | lifeskim:mentions | umls-concept:C0003467 | lld:lifeskim |
| pubmed-article:8095393 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:8095393 | lifeskim:mentions | umls-concept:C0040616 | lld:lifeskim |
| pubmed-article:8095393 | lifeskim:mentions | umls-concept:C0022885 | lld:lifeskim |
| pubmed-article:8095393 | lifeskim:mentions | umls-concept:C0392366 | lld:lifeskim |
| pubmed-article:8095393 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8095393 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:8095393 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8095393 | pubmed:dateCreated | 1993-4-15 | lld:pubmed |
| pubmed-article:8095393 | pubmed:abstractText | Rats of the selectively bred alcohol-preferring P and alcohol-nonpreferring NP lines were evaluated using three different behavioral measures of anxiety. Compared with NP rats, P rats (1) showed greater footshock-induced suppression of operant responding in an approach-avoidance conflict test; (2) spent less time in the open arms of an elevated plus maze; and (3) took longer in a passive avoidance test to step down from a platform to a grid floor where footshock was received 24 hours earlier. These findings indicate a greater degree of anxiety in the P than in the NP line of rats in these situations. Pretreatment with intraperitoneal (IP) ethanol (0.5-1.0 g/kg) injections produced anticonflict or anxiolytic effects in P but not in NP rats. However, the anticonflict effects of ethanol were small relative to those produced by chlordiazepoxide (CDP, 7.5 mg/kg) in both lines. The results demonstrate that selective breeding for divergent oral ethanol preference has produced associated differences between the P and NP lines of rats in behavioral tests of anxiety and in the anxiolytic effects of ethanol. | lld:pubmed |
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| pubmed-article:8095393 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8095393 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8095393 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8095393 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8095393 | pubmed:issn | 0741-8329 | lld:pubmed |
| pubmed-article:8095393 | pubmed:author | pubmed-author:LumengLL | lld:pubmed |
| pubmed-article:8095393 | pubmed:author | pubmed-author:LiT KTK | lld:pubmed |
| pubmed-article:8095393 | pubmed:author | pubmed-author:StewartR BRB | lld:pubmed |
| pubmed-article:8095393 | pubmed:author | pubmed-author:MurphyJ MJM | lld:pubmed |
| pubmed-article:8095393 | pubmed:author | pubmed-author:GattoG JGJ | lld:pubmed |
| pubmed-article:8095393 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8095393 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:8095393 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8095393 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8095393 | pubmed:pagination | 1-10 | lld:pubmed |
| pubmed-article:8095393 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8095393 | pubmed:articleTitle | Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol. | lld:pubmed |
| pubmed-article:8095393 | pubmed:affiliation | Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46205. | lld:pubmed |
| pubmed-article:8095393 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8095393 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8095393 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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