| pubmed-article:8093291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8093291 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:8093291 | lifeskim:mentions | umls-concept:C0080202 | lld:lifeskim |
| pubmed-article:8093291 | lifeskim:mentions | umls-concept:C0205161 | lld:lifeskim |
| pubmed-article:8093291 | lifeskim:mentions | umls-concept:C1709707 | lld:lifeskim |
| pubmed-article:8093291 | pubmed:issue | 8836 | lld:pubmed |
| pubmed-article:8093291 | pubmed:dateCreated | 1993-1-27 | lld:pubmed |
| pubmed-article:8093291 | pubmed:abstractText | Although vitamin A deficiency in children seems to increase susceptibility to infection and community trials have shown that vitamin A supplementation can reduce childhood mortality from infectious diseases, the underlying biological mechanisms are largely unknown. We conducted a randomised, double-masked, placebo-controlled clinical trial among children in West Java, Indonesia, to determine whether vitamin A deficiency is associated with abnormalities in T-cell subsets and whether vitamin A supplementation affects T-cell subsets. We studied 55 children aged 3-6 years--30 with xerophthalmia and 25 without. Acutely malnourished children (< 80% of reference weight-for-height) were excluded. CD4/CD8 ratios and the proportions of circulating CD4 naive, CD4 memory, CD8, CD45RA, and CD8, CD45RO T-cell subsets were measured. Children with xerophthalmia had lower CD4/CD8 ratios (p < 0.08), lower proportions of CD4 naive T cells (p < 0.03), and higher proportions of CD8, CD45RO T cells (p < 0.04) than those without xerophthalmia. 26 children were given vitamin A supplementation (60 mg retinol equivalent) and 29 received placebo. 5 weeks later the vitamin A group had higher CD4/CD8 ratios (p < 0.001), higher proportions of CD4 naive T cells (p < 0.01), and lower proportions of CD8, CD45RO T cells (p < 0.05) than the placebo group. Vitamin-A-deficient children have underlying immune abnormalities in T-cell subsets and these abnormalities are reversible with vitamin A supplementation. | lld:pubmed |
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| pubmed-article:8093291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8093291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8093291 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8093291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8093291 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8093291 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:8093291 | pubmed:author | pubmed-author:SommerAA | lld:pubmed |
| pubmed-article:8093291 | pubmed:author | pubmed-author:GriffinD EDE | lld:pubmed |
| pubmed-article:8093291 | pubmed:author | pubmed-author:WardB JBJ | lld:pubmed |
| pubmed-article:8093291 | pubmed:author | pubmed-author:WestK PKPJr | lld:pubmed |
| pubmed-article:8093291 | pubmed:author | pubmed-author:Muhilal | lld:pubmed |
| pubmed-article:8093291 | pubmed:author | pubmed-author:ScottA LAL | lld:pubmed |
| pubmed-article:8093291 | pubmed:author | pubmed-author:SembaR DRD | lld:pubmed |
| pubmed-article:8093291 | pubmed:author | pubmed-author:NatadisastraG... | lld:pubmed |
| pubmed-article:8093291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8093291 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:8093291 | pubmed:volume | 341 | lld:pubmed |
| pubmed-article:8093291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8093291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8093291 | pubmed:pagination | 5-8 | lld:pubmed |
| pubmed-article:8093291 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8093291 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8093291 | pubmed:articleTitle | Abnormal T-cell subset proportions in vitamin-A-deficient children. | lld:pubmed |
| pubmed-article:8093291 | pubmed:affiliation | Dana Center for Preventive Ophthalmology, Wilmer Institute, Baltimore, Maryland 21287-9019. | lld:pubmed |
| pubmed-article:8093291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8093291 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:8093291 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8093291 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8093291 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:8093291 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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