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8092990

Source:http://linkedlifedata.com/resource/pubmed/id/8092990

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pubmed-article:8092990pubmed:abstractTextThe expression of beta 2-adrenergic receptors is up-regulated by glucocorticoids. In contrast, beta 1-adrenergic receptors display glucocorticoid-induced down-regulation. In rat C6 glioma cells, which express both of these subtypes of beta-adrenergic receptors, the synthetic glucocorticoid dexamethasone stimulates no change in the total beta-adrenergic receptor content, but rather shifts the beta 1:beta 2 ratio from 80:20 to 50:50. Radioligand binding and immunoblotting demonstrate a sharp decline in beta 1-adrenergic receptor expression. Metabolic labelling of cells with [35S]-methionine in tandem with immunoprecipitation by beta 1-adrenergic-receptor-specific antibodies reveals a sharp decline in the synthesis of the receptor within 48 h for cells challenged with glucocorticoid. Steady-state levels of beta 1-adrenergic-receptor mRNA declined from 0.47 to 0.26 amol/microgram of total cellular RNA within 2 h of dexamethasone challenge, as measured by DNA-excess solution hybridization. The stability of receptor mRNA was not influenced by glucocorticoid; the half-lives of the beta 1- and beta 2-subtype mRNAs were 1.7 and 1.5 h respectively. Nuclear run-on assays revealed the basis for the down-regulation of receptor expression, i.e. a sharp decline in the relative rate of transcription for the beta 1-adrenergic-receptor gene in nuclei from dexamethasone-treated as compared with vehicle-treated cells. These data demonstrate transcriptional suppression as a molecular explanation for glucocorticoid-induced down-regulation of beta 1-adrenergic receptors.lld:pubmed
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pubmed-article:8092990pubmed:authorpubmed-author:MalbonC CCClld:pubmed
pubmed-article:8092990pubmed:authorpubmed-author:HadcockJ RJRlld:pubmed
pubmed-article:8092990pubmed:authorpubmed-author:BahouthS WSWlld:pubmed
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pubmed-article:8092990pubmed:articleTitleGlucocorticoids down-regulate beta 1-adrenergic-receptor expression by suppressing transcription of the receptor gene.lld:pubmed
pubmed-article:8092990pubmed:affiliationDepartment of Molecular Pharmacology, School of Medicine, University at Stony Brook, NY 11794-8651.lld:pubmed
pubmed-article:8092990pubmed:publicationTypeJournal Articlelld:pubmed
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