| pubmed-article:8092829 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C0002679 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C0064113 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C2350529 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:8092829 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:8092829 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8092829 | pubmed:dateCreated | 1994-10-17 | lld:pubmed |
| pubmed-article:8092829 | pubmed:abstractText | Itraconazole and amphotericin B were compared by using a newly developed model of invasive pulmonary aspergillosis in rabbits immunosuppressed with methylprednisolone and cyclosporin A (CsA). Both itraconazole at 40 mg/kg (given orally) and amphotericin B at 1 mg/kg (given intravenously) had in vivo antifungal activity in comparison with controls. At these dosages, amphotericin B was more effective than itraconazole in reducing the tissue burden (log10 CFU per gram) of Aspergillus fumigatus (P < 0.05) and the number of pulmonary lesions (P < 0.01). However, there was considerable variation in the near-peak concentrations of itraconazole in plasma (median, 4.15 micrograms/ml; range, < 0.5 to 16.8 micrograms/ml) and a strong inverse correlation between concentrations of itraconazole in plasma and the tissue burden of A. fumigatus. An inhibitory sigmoid maximum-effect model predicted a significant pharmacodynamic relationship (r = 0.87, P < 0.001) between itraconazole concentrations in plasma and antifungal activity as a function of the tissue burden of A. fumigatus. This model demonstrated that levels in plasma of greater than 6 micrograms/ml were associated with a significantly greater antifungal effect. Levels in plasma of less than 6 micrograms/ml were associated with a rapid decline in the antifungal effect. Itraconazole, in comparison with amphotericin B, caused a twofold elevation of CsA levels (P < 0.01) but was less nephrotoxic (P < 0.01). This study of experimental pulmonary aspergillosis demonstrated that amphotericin B at 1 mg/kg/day was more active but more nephrotoxic than itraconazole at 40 mg/kg/day, that itraconazole increased concentrations of CsA in plasma, and that the antifungal activity of itraconazole strongly correlated with concentrations in plasma in an inhibitory sigmoid maximum-effect model. These findings further indicate the importance of monitoring concentrations of itraconazole in plasma as a guide to increasing dosage, improving bioavailability, and optimizing antifungal efficacy in the treatment of invasive pulmonary aspergillosis. | lld:pubmed |
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| pubmed-article:8092829 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8092829 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8092829 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8092829 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8092829 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8092829 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:BerenguerJJ | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:LeeJJ | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:WalshT JTJ | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:BattagliaSS | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:PizzoP APA | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:RinaldiM GMG | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:PiscitelliS... | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:GarrettKK | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:AliN MNM | lld:pubmed |
| pubmed-article:8092829 | pubmed:author | pubmed-author:AllendeM CMC | lld:pubmed |
| pubmed-article:8092829 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8092829 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:8092829 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8092829 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8092829 | pubmed:pagination | 1303-8 | lld:pubmed |
| pubmed-article:8092829 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8092829 | pubmed:meshHeading | pubmed-meshheading:8092829-... | lld:pubmed |
| pubmed-article:8092829 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8092829 | pubmed:articleTitle | Itraconazole for experimental pulmonary aspergillosis: comparison with amphotericin B, interaction with cyclosporin A, and correlation between therapeutic response and itraconazole concentrations in plasma. | lld:pubmed |
| pubmed-article:8092829 | pubmed:affiliation | Infectious Diseases Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:8092829 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8092829 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8092829 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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