| pubmed-article:8086496 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8086496 | lifeskim:mentions | umls-concept:C0006413 | lld:lifeskim |
| pubmed-article:8086496 | lifeskim:mentions | umls-concept:C0212694 | lld:lifeskim |
| pubmed-article:8086496 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:8086496 | lifeskim:mentions | umls-concept:C0038592 | lld:lifeskim |
| pubmed-article:8086496 | lifeskim:mentions | umls-concept:C0883208 | lld:lifeskim |
| pubmed-article:8086496 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8086496 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:8086496 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8086496 | pubmed:dateCreated | 1994-10-14 | lld:pubmed |
| pubmed-article:8086496 | pubmed:abstractText | A double-stranded DNA-dependent protein serine/threonine kinase (DNA-PK) was purified from a nuclear extract of Raji Burkitt's lymphoma cells by a three-step column-chromatographic procedure. The main silver-stained band visualized after SDS/PAGE corresponded to an autophosphorylated polypeptide of about 350-kDa that represents the catalytic component. The existence of Ku DNA-binding protein as a regulatory component in the purified enzyme was revealed by Western blot/enzyme immunoassay and direct inhibition test with anti-Ku sera from the autoimmune patients. The DNA-PK catalyzed phosphorylation of synthetic peptides corresponding to Myc and RB proteins in a DNA-dependent manner, indicating that DNA-PK may recognize a second core-sequence motif Pro-Ser/Thr- in addition to the putative consensus sequences of -Ser/Thr-Gln. The level of enzyme activity was significantly higher in DMSO-induced G0/G1-arrested Raji cells as well as in the cells after release from DMSO than in the log-phase cells. | lld:pubmed |
| pubmed-article:8086496 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8086496 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8086496 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8086496 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8086496 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8086496 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8086496 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8086496 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8086496 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8086496 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8086496 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8086496 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:8086496 | pubmed:author | pubmed-author:TsukadaKK | lld:pubmed |
| pubmed-article:8086496 | pubmed:author | pubmed-author:WatanabeFF | lld:pubmed |
| pubmed-article:8086496 | pubmed:author | pubmed-author:IijimaSS | lld:pubmed |
| pubmed-article:8086496 | pubmed:author | pubmed-author:TeraokaHH | lld:pubmed |
| pubmed-article:8086496 | pubmed:author | pubmed-author:MimoriTT | lld:pubmed |
| pubmed-article:8086496 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8086496 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:8086496 | pubmed:volume | 1223 | lld:pubmed |
| pubmed-article:8086496 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8086496 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8086496 | pubmed:pagination | 255-60 | lld:pubmed |
| pubmed-article:8086496 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:meshHeading | pubmed-meshheading:8086496-... | lld:pubmed |
| pubmed-article:8086496 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8086496 | pubmed:articleTitle | Molecular properties, substrate specificity and regulation of DNA-dependent protein kinase from Raji Burkitt's lymphoma cells. | lld:pubmed |
| pubmed-article:8086496 | pubmed:affiliation | Department of Pathological Biochemistry, Tokyo Medical and Dental University, Japan. | lld:pubmed |
| pubmed-article:8086496 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8086496 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8086496 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8086496 | lld:pubmed |
