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pubmed-article:8083665pubmed:abstractTextCoxsackieviruses have been implicated as possible co-factors in the etiology of the selenium (Se)-responsive cardiomyopathy known as Keshan disease. Here we report that a cloned and sequenced amyocarditic coxsackievirus B3 (CVB3/0), which causes no pathology in the hearts of Se-adequate mice, induces extensive cardiac pathology in Se-deficient mice. CVB3/0 recovered from the hearts of Se-deficient mice inoculated into Se-adequate mice induced significant heart damage, suggesting mutation of the virus to a virulent genotype. We demonstrate the important role of host nutritional status in determining the severity of a viral infection.lld:pubmed
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pubmed-article:8083665pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:8083665pubmed:articleTitleBenign human enterovirus becomes virulent in selenium-deficient mice.lld:pubmed
pubmed-article:8083665pubmed:affiliationFrank Porter Graham Child Development Center, University of North Carolina, Chapel Hill.lld:pubmed
pubmed-article:8083665pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8083665pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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