| pubmed-article:8082705 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8082705 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8082705 | lifeskim:mentions | umls-concept:C0040114 | lld:lifeskim |
| pubmed-article:8082705 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:8082705 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:8082705 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:8082705 | pubmed:dateCreated | 1994-10-10 | lld:pubmed |
| pubmed-article:8082705 | pubmed:abstractText | We investigated the effects of facteur thymique sérique (FTS), a thymic peptide hormone, on alloxan- and streptozotocin-induced diabetes in rats. Pretreatment with intravenous injection of FTS significantly suppressed both alloxan- and streptozotocin-induced hyperglycemia. The effects of FTS were time dependent. FTS suppressed hyperglycemia in a dose range of 1-6600 micrograms/kg. Alloxan-induced hyperglycemia was completely prevented when FTS was injected in doses of 40-50 micrograms/kg 1 min before injection of alloxan. Histological examination of islet areas showed that alloxan-induced destruction of beta-cells was inhibited by FTS. FTS had no significant effects on lymphocyte subsets and immunity-related cells or on plasma superoxide dismutase activity and total glutathione level. The blood half-life time of exogenously injected FTS was short (2-3 min), indicating acute internalization of FTS into pancreatic beta-cells. Our results suggested that FTS acutely and directly blocks some initial effect of alloxan, preventing the destruction of beta-cells. | lld:pubmed |
| pubmed-article:8082705 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8082705 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8082705 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8082705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8082705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8082705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8082705 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8082705 | pubmed:month | May | lld:pubmed |
| pubmed-article:8082705 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:8082705 | pubmed:author | pubmed-author:ShinoharaTT | lld:pubmed |
| pubmed-article:8082705 | pubmed:author | pubmed-author:KojimaSS | lld:pubmed |
| pubmed-article:8082705 | pubmed:author | pubmed-author:AkaokaII | lld:pubmed |
| pubmed-article:8082705 | pubmed:author | pubmed-author:YamanouchiTT | lld:pubmed |
| pubmed-article:8082705 | pubmed:author | pubmed-author:MiyashitaHH | lld:pubmed |
| pubmed-article:8082705 | pubmed:author | pubmed-author:SekinoNN | lld:pubmed |
| pubmed-article:8082705 | pubmed:author | pubmed-author:MoromizatoHH | lld:pubmed |
| pubmed-article:8082705 | pubmed:author | pubmed-author:MinodaSS | lld:pubmed |
| pubmed-article:8082705 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8082705 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:8082705 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:8082705 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8082705 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8082705 | pubmed:pagination | 39-46 | lld:pubmed |
| pubmed-article:8082705 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
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| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
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| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:meshHeading | pubmed-meshheading:8082705-... | lld:pubmed |
| pubmed-article:8082705 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8082705 | pubmed:articleTitle | Prevention of diabetes by thymic hormone in alloxan-treated rats. | lld:pubmed |
| pubmed-article:8082705 | pubmed:affiliation | Second Department of Internal Medicine, University of Teikyo School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:8082705 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8082705 | lld:pubmed |
