Linked Life Data

8081873

Source:http://linkedlifedata.com/resource/pubmed/id/8081873

Statements in which the resource exists.
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pubmed-article:8081873pubmed:abstractTextThe cytokine termed hepatocyte growth factor or scatter factor (HGF/SF) has been implicated in embryonic development and liver regeneration. Mouse HGF/SF cDNA clones were obtained by screening a mouse liver cDNA library with synthetic oligonucleotides, as well as by using the method of reverse transcription-polymerase chain reaction (RT-PCR) with mRNA isolated from adult mouse brain. Sequence analysis of mouse HGF/SF cDNA clones spanning the entire coding region revealed an overall amino acid identity of 90% and 98% with human and rat HGF, respectively. Using mouse HGF antisense RNA as a probe, we observed the expression of HGF/SF mRNA in the liver, kidney, whole brain and cerebellum of adult mice as well as in day 9 and day 10 mouse embryos. The mouse HGF/SF cDNA was utilized for mapping Hgf to the centromeric region of mouse Chromosome 5 in apparent close proximity to the reeler mutation by the analysis of two multilocus crosses. The relationship of Hgf to the reeler mutation is discussed. The availability of mouse HGF/SF cDNA clones should facilitate further analysis of HGF/SF function during development.lld:pubmed
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pubmed-article:8081873pubmed:authorpubmed-author:YamadaK MKMlld:pubmed
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pubmed-article:8081873pubmed:pagination101-11lld:pubmed
pubmed-article:8081873pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:8081873pubmed:articleTitleStructure, genetic mapping, and expression of the mouse Hgf/scatter factor gene.lld:pubmed
pubmed-article:8081873pubmed:affiliationLaboratory of Developmental Biology, National Institute of Dental Research, NIH, Bethesda, MD 20892.lld:pubmed
pubmed-article:8081873pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8081873pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8081873pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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