| pubmed-article:8072849 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8072849 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:8072849 | lifeskim:mentions | umls-concept:C0225595 | lld:lifeskim |
| pubmed-article:8072849 | lifeskim:mentions | umls-concept:C0042305 | lld:lifeskim |
| pubmed-article:8072849 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:8072849 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:8072849 | lifeskim:mentions | umls-concept:C0076257 | lld:lifeskim |
| pubmed-article:8072849 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:8072849 | pubmed:dateCreated | 1994-9-26 | lld:pubmed |
| pubmed-article:8072849 | pubmed:abstractText | Fluoride (F-) a known stimulator of G-protein, has been reported to inhibit "P"-type ATPase activity in smooth muscles. On the other hand, vanadate, a strong "P"-type ATPase inhibitor, has been reported to stimulate G-protein in some cells. This study was designed to compare the contractile actions of fluoroaluminate (AlF4-) and vanadate and to clarify their mechanisms of actions by measuring changes in the amount of cyclic adenosine monophosphate (cAMP) and inositol phosphates. F- and vanadate induced strong contractions in canine trachealis muscle. The F(-)-induced contraction was potentiated by the addition of aluminum (Al3+, 20 microM) and inhibited by deferoxamine (200 microM), a heavy metal chelator. Ca2+ removal and 10 microM verapamil inhibited the contraction induced by AlF4- and vanadate. AlF4- and vanadate increased 45Ca influx in the absence and presence of verapamil. AlF4(-)-induced contractions were partially relaxed by isoproterenol (38.2 +/- 7.4%) in contrast with those induced by vanadate (72.1 +/- 5.3%), which could be explained by a decrease of tissue cAMP content by AlF4- in forskolin-pretreated tissues. Vanadate increased inositol phosphate accumulation as did AlF4-, although the magnitude of the increase was smaller than that produced by AlF4-. The increases of inositol phosphate content by both drugs were not affected after the pretreatment by pertussis toxin.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:8072849 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8072849 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072849 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8072849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072849 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8072849 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8072849 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:8072849 | pubmed:author | pubmed-author:LeeS HSH | lld:pubmed |
| pubmed-article:8072849 | pubmed:author | pubmed-author:JungJ SJS | lld:pubmed |
| pubmed-article:8072849 | pubmed:author | pubmed-author:HwangT HTH | lld:pubmed |
| pubmed-article:8072849 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8072849 | pubmed:volume | 427 | lld:pubmed |
| pubmed-article:8072849 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8072849 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8072849 | pubmed:pagination | 295-300 | lld:pubmed |
| pubmed-article:8072849 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8072849 | pubmed:meshHeading | pubmed-meshheading:8072849-... | lld:pubmed |
| pubmed-article:8072849 | pubmed:meshHeading | pubmed-meshheading:8072849-... | lld:pubmed |
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| pubmed-article:8072849 | pubmed:meshHeading | pubmed-meshheading:8072849-... | lld:pubmed |
| pubmed-article:8072849 | pubmed:meshHeading | pubmed-meshheading:8072849-... | lld:pubmed |
| pubmed-article:8072849 | pubmed:meshHeading | pubmed-meshheading:8072849-... | lld:pubmed |
| pubmed-article:8072849 | pubmed:meshHeading | pubmed-meshheading:8072849-... | lld:pubmed |
| pubmed-article:8072849 | pubmed:meshHeading | pubmed-meshheading:8072849-... | lld:pubmed |
| pubmed-article:8072849 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8072849 | pubmed:articleTitle | Differential actions of AlF4- and vanadate on canine trachealis muscle. | lld:pubmed |
| pubmed-article:8072849 | pubmed:affiliation | Department of Physiology, College of Medicine, Pusan National University, Korea. | lld:pubmed |
| pubmed-article:8072849 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8072849 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
