| pubmed-article:8072245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8072245 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:8072245 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8072245 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:8072245 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:8072245 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:8072245 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:8072245 | lifeskim:mentions | umls-concept:C0041956 | lld:lifeskim |
| pubmed-article:8072245 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:8072245 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8072245 | pubmed:dateCreated | 1994-9-27 | lld:pubmed |
| pubmed-article:8072245 | pubmed:abstractText | Unilateral ureteral obstruction (UUO) in the neonate increases ipsilateral renal renin gene expression, an effect which is mediated by renal nerves. To determine whether neonatal UUO alters the number of renal cortical cells secreting renin and whether this change is modulated by renal nerve activity, newborn Sprague-Dawley rats were subjected to left UUO, right uninephrectomy, or sham operation and studied four weeks thereafter. To evaluate the importance of renal nerves in this response, an additional group of animals underwent chemical sympathectomy with guanethidine. Ureteral obstruction was associated with marked reduction in renal mass in the obstructed kidney and contralateral compensatory hypertrophy, changes which were not altered by sympathectomy. Renin messenger RNA and renal renin content were elevated in the obstructed kidney. The number of cells secreting renin, measured by the reverse hemolytic plaque assay, was markedly increased in the obstructed kidney (45 +/- 18 plaques/slide vs. 11 +/- 1 plaques/slide in sham animals), but not in the opposite kidney or following uninephrectomy. This effect was not significantly altered by sympathectomy. There was no change in the amount of renin secreted per cell or in the secretory response to Ca++. These results show that UUO results in recruitment of cells not previously secreting renin by a mechanism independent of renal nerve activity. This recruitment occurs without alteration of the quantity of renin secreted per cell or in the normal regulatory effect of Ca++ on renin secretion. An increase in the number of renin-secreting cells may contribute to the activation of the renin-angiotensin system, and thus to the vasoconstriction observed following ureteral obstruction. | lld:pubmed |
| pubmed-article:8072245 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072245 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072245 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072245 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8072245 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072245 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8072245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8072245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8072245 | pubmed:month | May | lld:pubmed |
| pubmed-article:8072245 | pubmed:issn | 0085-2538 | lld:pubmed |
| pubmed-article:8072245 | pubmed:author | pubmed-author:CareyR MRM | lld:pubmed |
| pubmed-article:8072245 | pubmed:author | pubmed-author:JoseP APA | lld:pubmed |
| pubmed-article:8072245 | pubmed:author | pubmed-author:ChevalierR... | lld:pubmed |
| pubmed-article:8072245 | pubmed:author | pubmed-author:GomezR ARA | lld:pubmed |
| pubmed-article:8072245 | pubmed:author | pubmed-author:GearyK MKM | lld:pubmed |
| pubmed-article:8072245 | pubmed:author | pubmed-author:NorwoodV FVF | lld:pubmed |
| pubmed-article:8072245 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8072245 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:8072245 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8072245 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8072245 | pubmed:pagination | 1333-9 | lld:pubmed |
| pubmed-article:8072245 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8072245 | pubmed:meshHeading | pubmed-meshheading:8072245-... | lld:pubmed |
| pubmed-article:8072245 | pubmed:meshHeading | pubmed-meshheading:8072245-... | lld:pubmed |
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| pubmed-article:8072245 | pubmed:meshHeading | pubmed-meshheading:8072245-... | lld:pubmed |
| pubmed-article:8072245 | pubmed:meshHeading | pubmed-meshheading:8072245-... | lld:pubmed |
| pubmed-article:8072245 | pubmed:meshHeading | pubmed-meshheading:8072245-... | lld:pubmed |
| pubmed-article:8072245 | pubmed:meshHeading | pubmed-meshheading:8072245-... | lld:pubmed |
| pubmed-article:8072245 | pubmed:meshHeading | pubmed-meshheading:8072245-... | lld:pubmed |
| pubmed-article:8072245 | pubmed:meshHeading | pubmed-meshheading:8072245-... | lld:pubmed |
| pubmed-article:8072245 | pubmed:meshHeading | pubmed-meshheading:8072245-... | lld:pubmed |
| pubmed-article:8072245 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8072245 | pubmed:articleTitle | Neonatal ureteral obstruction stimulates recruitment of renin-secreting renal cortical cells. | lld:pubmed |
| pubmed-article:8072245 | pubmed:affiliation | Department of Pediatrics, University of Virginia, Charlottesville. | lld:pubmed |
| pubmed-article:8072245 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8072245 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8072245 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8072245 | lld:pubmed |
