| pubmed-article:8063776 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0678222 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0035339 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:8063776 | lifeskim:mentions | umls-concept:C1706701 | lld:lifeskim |
| pubmed-article:8063776 | pubmed:issue | 34 | lld:pubmed |
| pubmed-article:8063776 | pubmed:dateCreated | 1994-9-22 | lld:pubmed |
| pubmed-article:8063776 | pubmed:abstractText | Retinoids mediate their actions via RARs (retinoic acid receptors) and RXRs (retinoid X receptors). Each class of these nuclear retinoid receptors is further subdivided into three species, namely alpha, beta, and gamma. Recent studies demonstrate that estrogen receptor (ER)-positive human breast carcinoma (HBC) cell lines and tumor samples exhibit significantly higher levels of RAR alpha than their ER-negative counterparts. ER-positive HBC cell lines are sensitive to, and ER-negative cell lines are resistant to, growth inhibitory effects of retinoic acid (RA). We previously demonstrated that the expression of functional ERs in an established ER-negative cell line resulted in higher levels of RAR alpha and sensitivity to growth inhibition by RA. To further investigate the major role of RAR alpha in retinoid-mediated inhibition of growth, we transfected RAR alpha cDNA in two RA-resistant ER-negative HBC cell lines. Analyses of different clonal populations of RAR alpha transfectants from each cell line revealed growth inhibition by retinoids. Utilizing RAR- and RXR-class selective retinoids, we further demonstrated that only the RAR alpha-selective retinoids mediated the growth inhibition in these cells, while the RXR-selective retinoids were biologically inert. We thus provide evidence that the molecular mechanisms of retinoid inhibition of HBC proliferation predominantly involve RAR alpha. | lld:pubmed |
| pubmed-article:8063776 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8063776 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8063776 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8063776 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8063776 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8063776 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8063776 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:DawsonMM | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:WuSS | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:GarciaMM | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:RochefortHH | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:JettenA MAM | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:FontanaJ AJA | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:SheikhM SMS | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:ShaoZ MZM | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:LiX SXS | lld:pubmed |
| pubmed-article:8063776 | pubmed:author | pubmed-author:ConleyB ABA | lld:pubmed |
| pubmed-article:8063776 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8063776 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:8063776 | pubmed:volume | 269 | lld:pubmed |
| pubmed-article:8063776 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8063776 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8063776 | pubmed:pagination | 21440-7 | lld:pubmed |
| pubmed-article:8063776 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8063776 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8063776 | pubmed:articleTitle | Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-alpha acquire sensitivity to growth inhibition by retinoids. | lld:pubmed |
| pubmed-article:8063776 | pubmed:affiliation | Department of Medicine, University of Maryland School of Medicine, Baltimore. | lld:pubmed |
| pubmed-article:8063776 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8063776 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8063776 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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