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pubmed-article:806256pubmed:abstractTextThe effect of isoniazid on the protoplasmic viscosity in the H37Ra strain of Mycobacterium tuberculosis was determined by using electron spin resonance spectroscopy and a small spin label tempone (2,2,6,6-tetramethylpiperidone-N-oxyl radical). Isoniazid (0.5 mug/ml) caused the internal cellular viscosity to increase gradually over the first 15 h of exposure from a rotational correlation time value (T(c)) of 2.4 x 10(-10) to 3.4 x 10(10) s and then decrease linearly to the control level after 27 h. These results could be interpreted to mean that isoniazid allows a continued and normal synthesis of the protoplasmic components while the rate of increase in the cell volume is reduced. A degradative process may begin after the initial 15-h exposure time, which would cause the reduction in the internal viscosity.lld:pubmed
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pubmed-article:806256pubmed:authorpubmed-author:TakayamaKKlld:pubmed
pubmed-article:806256pubmed:authorpubmed-author:KeithA DADlld:pubmed
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pubmed-article:806256pubmed:pagination22-4lld:pubmed
pubmed-article:806256pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:806256pubmed:year1975lld:pubmed
pubmed-article:806256pubmed:articleTitleEffect of isoniazid on the protoplasmic viscosity in Mycobacterium tuberculosis.lld:pubmed
pubmed-article:806256pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:806256pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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