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pubmed-article:8054253pubmed:abstractTextThe antiarrhythmic properties of sublingual verapamil were investigated in seven patients with acute fast atrial flutter (n = 2) or fibrillation (n = 5). A rapid and significant (P < 0.05) reduction in the ventricular rate was achieved in all seven patients. The ventricular rate at peak plasma verapamil concentration (+/- s.d.) was significantly slower than on admission (101.6 +/- 11.3 and 159 +/- 5.3 beats min-1 respectively, P < 0.01). The ventricular rate remained controlled for over 4 h. Sublingual verapamil was rapidly absorbed with the maximum peak plasma concentration (153.3 +/- 15.5 ng ml-1) being achieved after 1.21 +/- 0.18 h. Side-effects of sublingual verapamil were limited to one report of a bitter taste. The sublingual administration of verapamil may provide an alternative method for the control of acute fast atrial fibrillation and flutter in selected patients.lld:pubmed
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pubmed-article:8054253pubmed:articleTitlePreliminary investigation of the efficacy of sublingual verapamil in the management of acute atrial fibrillation and flutter.lld:pubmed
pubmed-article:8054253pubmed:affiliationCardiology Department, Western General Hospital, Edinburgh.lld:pubmed
pubmed-article:8054253pubmed:publicationTypeJournal Articlelld:pubmed