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pubmed-article:8053598pubmed:abstractTextIn the guinea pig, depleting hepatic glutathione before inhaling subanesthetic 0.1% halothane increases covalent binding of halothane biotransformation intermediates to hepatic protein and potentiates resultant liver injury. Because inhalation of a higher concentration of halothane is known to produce greater levels of covalent binding than with subanesthetic halothane, this study was undertaken with 0.25-1.0% halothane concentrations to further examine glutathione depletion as an etiology for halothane hepatitis.lld:pubmed
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pubmed-article:8053598pubmed:authorpubmed-author:GandolfiA JAJlld:pubmed
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pubmed-article:8053598pubmed:articleTitleA model for fatal halothane hepatitis in the guinea pig.lld:pubmed
pubmed-article:8053598pubmed:affiliationDepartment of Anesthesiology, College of Medicine, University of Arizona, Tucson.lld:pubmed
pubmed-article:8053598pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8053598pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed