| pubmed-article:8052232 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8052232 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8052232 | lifeskim:mentions | umls-concept:C1449847 | lld:lifeskim |
| pubmed-article:8052232 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:8052232 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:8052232 | lifeskim:mentions | umls-concept:C1158774 | lld:lifeskim |
| pubmed-article:8052232 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:8052232 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8052232 | pubmed:dateCreated | 1994-9-2 | lld:pubmed |
| pubmed-article:8052232 | pubmed:abstractText | The glucose kinase gene (glkA-ORF3) of Streptomyces coelicolor A3(2) plays an essential role in glucose utilisation and in glucose repression of a variety of genes involved in the utilisation of alternative carbon sources. These genes include dagA, which encodes an extracellular agarase that permits agar utilisation. Suppressor mutants of glkA-ORF3 deletion strains capable of utilising glucose (Glc+) arise at a frequency of about 10(-5) on prolonged incubation. The Glc+ phenotype of the mutants is reversible (at a frequency of about 10(-3) and reflects either the activation of a normally silent glucose kinase gene or the modification of an existing sugar kinase. Although the level of glucose kinase activity in the Glc+ supressor mutants is similar to that in the glkA+ parental strain, glucose repression of dagA remains defective. Expression of the glucose kinase gene of Zymomonas mobilis in glkA-ORF3 mutants restored glucose utilisation, but not glucose repression of dagA. Over-expression of glkA-ORF3 on a high-copy-number plasmid failed to restore glucose repression of dagA in glkA-ORF3 mutants and led to loss of glucose repression of dagA in a glkA+ strain. These results suggest that glucose phosphorylation itself is not sufficient for glucose repression and that glkA-ORF3 plays a specific regulatory role in triggering glucose repression in S. coelicolor A3(2). | lld:pubmed |
| pubmed-article:8052232 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8052232 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8052232 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8052232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8052232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8052232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8052232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8052232 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8052232 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8052232 | pubmed:issn | 0026-8925 | lld:pubmed |
| pubmed-article:8052232 | pubmed:author | pubmed-author:BibbM JMJ | lld:pubmed |
| pubmed-article:8052232 | pubmed:author | pubmed-author:LewisC GCG | lld:pubmed |
| pubmed-article:8052232 | pubmed:author | pubmed-author:AngellSS | lld:pubmed |
| pubmed-article:8052232 | pubmed:author | pubmed-author:ButtnerM JMJ | lld:pubmed |
| pubmed-article:8052232 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8052232 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:8052232 | pubmed:volume | 244 | lld:pubmed |
| pubmed-article:8052232 | pubmed:geneSymbol | dagA | lld:pubmed |
| pubmed-article:8052232 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8052232 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8052232 | pubmed:pagination | 135-43 | lld:pubmed |
| pubmed-article:8052232 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8052232 | pubmed:meshHeading | pubmed-meshheading:8052232-... | lld:pubmed |
| pubmed-article:8052232 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8052232 | pubmed:articleTitle | Glucose repression in Streptomyces coelicolor A3(2): a likely regulatory role for glucose kinase. | lld:pubmed |
| pubmed-article:8052232 | pubmed:affiliation | John Innes Centre, Colney, Norwich, UK. | lld:pubmed |
| pubmed-article:8052232 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8052232 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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