| pubmed-article:8036704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8036704 | lifeskim:mentions | umls-concept:C0522537 | lld:lifeskim |
| pubmed-article:8036704 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:8036704 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:8036704 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8036704 | pubmed:dateCreated | 1994-8-16 | lld:pubmed |
| pubmed-article:8036704 | pubmed:abstractText | A new strategy based on a clonal reduction hypothesis has been developed for prolonging concordant cardiac xenograft survival. Splenocytes from Golden Syrian hamsters were transfused intravenously into Lewis rats 14 days before the time of a donor-specific heart transplant into the recipient. Cyclophosphamide was administered from days -11 to -7 to reduce or eliminate proliferating xenoreactive clones. Low dose CsA was administered after the cyclophosphamide to prevent emergence and expression of xenoreactive cells. Finally, rapamycin 1.0 mg/kg was given for 5 days after transplant as further immunosuppression since it acts synergistically with CsA. In the group that received no immunosuppression after day +8, mean graft survival was 33.2 +/- 7.0 days with 10 of 17 xenografts surviving > 28 days. Extending either CsA therapy or rapamycin therapy after day +8 did not prolong graft survival. Each component of the therapy was found to be necessary for the effect. | lld:pubmed |
| pubmed-article:8036704 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8036704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8036704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8036704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8036704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8036704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8036704 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8036704 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:8036704 | pubmed:author | pubmed-author:LevyAA | lld:pubmed |
| pubmed-article:8036704 | pubmed:author | pubmed-author:GalliCC | lld:pubmed |
| pubmed-article:8036704 | pubmed:author | pubmed-author:AlexanderJ... | lld:pubmed |
| pubmed-article:8036704 | pubmed:author | pubmed-author:MasroorSS | lld:pubmed |
| pubmed-article:8036704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8036704 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8036704 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:8036704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8036704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8036704 | pubmed:pagination | 14-7 | lld:pubmed |
| pubmed-article:8036704 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:meshHeading | pubmed-meshheading:8036704-... | lld:pubmed |
| pubmed-article:8036704 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8036704 | pubmed:articleTitle | A new strategy for prolonging xenograft survival. | lld:pubmed |
| pubmed-article:8036704 | pubmed:affiliation | Department of Surgery, University of Cincinnati Medical Center, Ohio 45267-0558. | lld:pubmed |
| pubmed-article:8036704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8036704 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8036704 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
