| pubmed-article:8036004 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:8036004 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:8036004 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8036004 | pubmed:dateCreated | 1994-8-15 | lld:pubmed |
| pubmed-article:8036004 | pubmed:abstractText | The transcriptional down-regulation of the major histocompatibility complex (MHC) class I antigens in adenovirus type 12 (Ad12) transformed cells gives them the potential to escape immunosurveillance and to form tumors. The enhancer of the class I promoter is the target of transcriptional repression which is mediated by the E1A gene of Ad12. The R2 region within the class I enhancer acts as a negative element in Ad12-transformed cells and exhibits a stronger binding activity than is observed in nontumorigenic Ad5-transformed cells, which are not reduced in class I expression. The R2 element contains a nuclear hormone receptor half-site consensus sequence, AGGTCA, which is required for both the binding activity and the ability of R2 to act as a negative element in Ad12-transformed cells. In this study, we show that an orphan hormone receptor protein, COUP-TF, contributes to the differential R2 binding activity observed between Ad12- and Ad5-transformed cells. Additionally, COUP-TF was shown to bind as a dimer to the R2 element and to use the consensus AGGTCA as one half-site and its 3' flanking sequence as a probable second degenerate half-site. Since COUP-TF can act as a transcriptional repressor, we suggest that the higher COUP-TF binding activity to the R2 element in Ad12-transformed cells contributes to down-regulation of class I transcription and, consequently, tumorigenesis. | lld:pubmed |
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| pubmed-article:8036004 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8036004 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8036004 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8036004 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8036004 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8036004 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8036004 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:8036004 | pubmed:author | pubmed-author:LimPP | lld:pubmed |
| pubmed-article:8036004 | pubmed:author | pubmed-author:TsaiM JMJ | lld:pubmed |
| pubmed-article:8036004 | pubmed:author | pubmed-author:TsaoS SSS | lld:pubmed |
| pubmed-article:8036004 | pubmed:author | pubmed-author:RicciardiR... | lld:pubmed |
| pubmed-article:8036004 | pubmed:author | pubmed-author:FuCC | lld:pubmed |
| pubmed-article:8036004 | pubmed:author | pubmed-author:CooneyA JAJ | lld:pubmed |
| pubmed-article:8036004 | pubmed:author | pubmed-author:WestmorelandS... | lld:pubmed |
| pubmed-article:8036004 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8036004 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:8036004 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8036004 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8036004 | pubmed:pagination | 2183-90 | lld:pubmed |
| pubmed-article:8036004 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8036004 | pubmed:meshHeading | pubmed-meshheading:8036004-... | lld:pubmed |
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| pubmed-article:8036004 | pubmed:meshHeading | pubmed-meshheading:8036004-... | lld:pubmed |
| pubmed-article:8036004 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8036004 | pubmed:articleTitle | Negative regulation by the R2 element of the MHC class I enhancer in adenovirus-12 transformed cells correlates with high levels of COUP-TF binding. | lld:pubmed |
| pubmed-article:8036004 | pubmed:affiliation | Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104. | lld:pubmed |
| pubmed-article:8036004 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8036004 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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