pubmed-article:8035203 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
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pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0017651 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0014298 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0018546 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0066908 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:8035203 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
pubmed-article:8035203 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:8035203 | pubmed:dateCreated | 1994-8-12 | lld:pubmed |
pubmed-article:8035203 | pubmed:abstractText | The mRNA encoding mu-opioid receptors is expressed in neurons of the globus pallidus, a region of the basal ganglia that receives a dense enkephalinergic innervation from the striatum. The regulation of the mRNAs encoding the opioid peptide enkephalin in the striatum and the mu-opioid receptor in the globus pallidus was examined with in situ hybridization histochemistry following short- or long-term haloperidol treatments, which alter striatal enkephalin mRNA levels. Animals were administered haloperidol daily for 3 or 7 days (1 mg/kg, s.c.) or continuously for 8 months (1 mg/kg, depot followed by oral). Enkephalin and mu-opioid receptor mRNA levels were unchanged after 3 days of haloperidol treatment. In contrast, the enkephalin mRNA level was increased in the striatum, and mu-opioid receptor mRNA levels were markedly decreased in the globus pallidus after 7 days of haloperidol administration. Similar effects were observed in rats treated with haloperidol for 8 months. The results provide the first evidence of regulation of mu-opioid receptor mRNA in vivo. | lld:pubmed |
pubmed-article:8035203 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8035203 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8035203 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8035203 | pubmed:language | eng | lld:pubmed |
pubmed-article:8035203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8035203 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8035203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8035203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8035203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8035203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8035203 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8035203 | pubmed:month | Aug | lld:pubmed |
pubmed-article:8035203 | pubmed:issn | 0022-3042 | lld:pubmed |
pubmed-article:8035203 | pubmed:author | pubmed-author:YuLL | lld:pubmed |
pubmed-article:8035203 | pubmed:author | pubmed-author:ReisineTT | lld:pubmed |
pubmed-article:8035203 | pubmed:author | pubmed-author:EllisonG DGD | lld:pubmed |
pubmed-article:8035203 | pubmed:author | pubmed-author:ChesseletM... | lld:pubmed |
pubmed-article:8035203 | pubmed:author | pubmed-author:DelfsJ MJM | lld:pubmed |
pubmed-article:8035203 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8035203 | pubmed:volume | 63 | lld:pubmed |
pubmed-article:8035203 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8035203 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8035203 | pubmed:pagination | 777-80 | lld:pubmed |
pubmed-article:8035203 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
pubmed-article:8035203 | pubmed:meshHeading | pubmed-meshheading:8035203-... | lld:pubmed |
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pubmed-article:8035203 | pubmed:meshHeading | pubmed-meshheading:8035203-... | lld:pubmed |
pubmed-article:8035203 | pubmed:year | 1994 | lld:pubmed |
pubmed-article:8035203 | pubmed:articleTitle | Regulation of mu-opioid receptor mRNA in rat globus pallidus: effects of enkephalin increases induced by short- and long-term haloperidol administration. | lld:pubmed |
pubmed-article:8035203 | pubmed:affiliation | Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104. | lld:pubmed |
pubmed-article:8035203 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8035203 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:8035203 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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