| pubmed-article:8032598 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8032598 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8032598 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8032598 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:8032598 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:8032598 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:8032598 | lifeskim:mentions | umls-concept:C0022660 | lld:lifeskim |
| pubmed-article:8032598 | lifeskim:mentions | umls-concept:C0033262 | lld:lifeskim |
| pubmed-article:8032598 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8032598 | lifeskim:mentions | umls-concept:C0119473 | lld:lifeskim |
| pubmed-article:8032598 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8032598 | pubmed:dateCreated | 1994-8-17 | lld:pubmed |
| pubmed-article:8032598 | pubmed:abstractText | 1. In this study the renal selectivity of dopamine and its prodrugs L-dopa and gludopa, with respect to their effects on regional blood flow, vascular resistance and central haemodynamics was investigated in normal rats and in rats with glycerol-induced acute renal failure (ARF). 2. In normal, anaesthetized rats, dopamine as well as its prodrugs caused a dose-dependent reduction of vascular resistance in the kidney (RR), mesentery (MR) and hindquarters (HQR) (dose range: dopamine: 0.1-5 mumol kg-1 h-1; L-dopa and gludopa: 1-200 mumol kg-1 h-1). Blood pressure and heart rate were affected at the highest dose only. 3. Administration of glycerol induced a preferential renal vasoconstriction; renal blood flow (-60%) and vascular resistance (+190%) were significantly more affected than MR (+40%) and HQR (+60%). This was only ameliorated by a low rate (10 mumol kg-1 h-1) infusion of gludopa: the glycerol-induced reduction of renal flow and increase in RR were significantly attenuated. A high dose of gludopa (100 mumol kg-1 h-1) or any dose of L-dopa or dopamine did not induce this beneficial effect. The glycerol-induced increase in MR and HQR was not attenuated by any of the treatments used. 4. The results indicate that gludopa is not renally selective at a pharmacodynamic level in normal, anaesthetized rats. Contrary to this, a low dose of gludopa does cause a renal selective vasodilatation and reduction of RR in rats with glycerol-induced ARF. This difference could be explained by a difference in renal vascular tone between normal rats and glycerol-induced ARF rats. A high dose ofgludopa does not cause these renal-selective effects: renal resistance and renal flow are at the same level as following glycerol and saline. This is probably due to the systemic effects of the released dopamine. | lld:pubmed |
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| pubmed-article:8032598 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8032598 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8032598 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8032598 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8032598 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8032598 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:8032598 | pubmed:author | pubmed-author:SmithJ SJS | lld:pubmed |
| pubmed-article:8032598 | pubmed:author | pubmed-author:van EssenHH | lld:pubmed |
| pubmed-article:8032598 | pubmed:author | pubmed-author:ThijssenH HHH | lld:pubmed |
| pubmed-article:8032598 | pubmed:author | pubmed-author:Struijker... | lld:pubmed |
| pubmed-article:8032598 | pubmed:author | pubmed-author:DriemanJ CJC | lld:pubmed |
| pubmed-article:8032598 | pubmed:author | pubmed-author:van KanF JFJ | lld:pubmed |
| pubmed-article:8032598 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8032598 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:8032598 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8032598 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8032598 | pubmed:pagination | 1117-22 | lld:pubmed |
| pubmed-article:8032598 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:8032598 | pubmed:meshHeading | pubmed-meshheading:8032598-... | lld:pubmed |
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| pubmed-article:8032598 | pubmed:meshHeading | pubmed-meshheading:8032598-... | lld:pubmed |
| pubmed-article:8032598 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8032598 | pubmed:articleTitle | Regional haemodynamic effects of dopamine and its prodrugs L-dopa and gludopa in the rat and in the glycerol-treated rat as a model for acute renal failure. | lld:pubmed |
| pubmed-article:8032598 | pubmed:affiliation | Department of Pharmacology, University of Limburg, Maastricht, The Netherlands. | lld:pubmed |
| pubmed-article:8032598 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8032598 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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