| pubmed-article:8028014 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8028014 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:8028014 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:8028014 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:8028014 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:8028014 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8028014 | lifeskim:mentions | umls-concept:C0574032 | lld:lifeskim |
| pubmed-article:8028014 | lifeskim:mentions | umls-concept:C0475224 | lld:lifeskim |
| pubmed-article:8028014 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:8028014 | lifeskim:mentions | umls-concept:C0439590 | lld:lifeskim |
| pubmed-article:8028014 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8028014 | pubmed:dateCreated | 1994-8-11 | lld:pubmed |
| pubmed-article:8028014 | pubmed:abstractText | Our aim was to determine whether adenosine A1 receptor-mediated protection could be maintained for a prolonged period of time by a continuous infusion of an A1-selective agonist. To produce myocardial infarction a branch of the left coronary artery of rabbit hearts was occluded for 30 min and reperfused for 3 h. Infarct size was determined with tetrazolium staining. Prior to the 30 min ischaemia, rabbits were subjected to one of the following six protocols: (1) 6 h i.v. saline infusion; (2) 6 h i.v. CCPA (0.043 mg/kg/h) infusion; (3) 72 h saline infusion; (4) 72 h CCPA infusion; (5) 72 h CCPA infusion plus preconditioning with 5 min ischaemia followed by 10 min reperfusion; (6) 72 h saline infusion plus preconditioning. The 6 h CCPA infusion group had significantly smaller infarct sizes than the 6 h vehicle group. 16.2 +/- 2.9% infarction of the ischaemic region v 39.5 +/- 2.6%, P < 0.01. Infarction in the 72 h CCPA infusion group (37.7 +/- 2.7%) was the same as in the 72 h vehicle group (35.2 +/- 3.1%). Ischaemic preconditioning could not limit infarct size in 72 h CCPA animals (%infarction; 29.1 +/- 4.6%) but did protect animals given vehicle for 72 h (8.4 +/- 1.2%, P < 0.01). After 72 h infusion of CCPA, both the cardioprotective effect of adenosine A1-selective agonist and ischaemic preconditioning were attenuated. These findings indicate that: (1) the myocytes become desensitized to the protective effect of CCPA with prolonged exposure; and (2) ischaemic preconditioning is no longer protective when tachyphylaxis to CCPA occurs. | lld:pubmed |
| pubmed-article:8028014 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8028014 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8028014 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8028014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8028014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8028014 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8028014 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8028014 | pubmed:issn | 0022-2828 | lld:pubmed |
| pubmed-article:8028014 | pubmed:author | pubmed-author:DownerJ DJD | lld:pubmed |
| pubmed-article:8028014 | pubmed:author | pubmed-author:ThompsonRR | lld:pubmed |
| pubmed-article:8028014 | pubmed:author | pubmed-author:OlssonR ARA | lld:pubmed |
| pubmed-article:8028014 | pubmed:author | pubmed-author:TsuchidaAA | lld:pubmed |
| pubmed-article:8028014 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8028014 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:8028014 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8028014 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8028014 | pubmed:pagination | 303-11 | lld:pubmed |
| pubmed-article:8028014 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8028014 | pubmed:meshHeading | pubmed-meshheading:8028014-... | lld:pubmed |
| pubmed-article:8028014 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8028014 | pubmed:articleTitle | The anti-infarct effect of an adenosine A1-selective agonist is diminished after prolonged infusion as is the cardioprotective effect of ischaemic preconditioning in rabbit heart. | lld:pubmed |
| pubmed-article:8028014 | pubmed:affiliation | Department of Physiology, University of South Alabama, Mobile 36688. | lld:pubmed |
| pubmed-article:8028014 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8028014 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8028014 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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