| pubmed-article:8027984 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8027984 | lifeskim:mentions | umls-concept:C0021242 | lld:lifeskim |
| pubmed-article:8027984 | lifeskim:mentions | umls-concept:C0032172 | lld:lifeskim |
| pubmed-article:8027984 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:8027984 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8027984 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:8027984 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8027984 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:8027984 | pubmed:dateCreated | 1994-8-9 | lld:pubmed |
| pubmed-article:8027984 | pubmed:abstractText | (2RS,4R)-3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles represent a new class of potent, orally active antagonists of platelet activating factor (PAF). The compounds were prepared by acylation of the magnesium or zinc salts of substituted indoles with (2RS,4R)-2-(3-pyridinyl)-3-(tert-butoxycarbonyl)thiazolidin-4-oyl chloride. The 3-acylindole moiety functions as a hydrolytically stabilized and conformationally restricted anilide replacement, which imparts a considerable boost in potency to the series. Structure-activity relationships observed for substitution on the indole ring system are discussed. Members of the series compare favorably with other reported PAF antagonists. | lld:pubmed |
| pubmed-article:8027984 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8027984 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027984 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8027984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8027984 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8027984 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8027984 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:PhillipsJ GJG | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:MayP DPD | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:DavidsenS KSK | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:HeymanH RHR | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:GuinnD EDE | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:BuresM GMG | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:CarreraG... | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:SteinmanD HDH | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:PirehDD | lld:pubmed |
| pubmed-article:8027984 | pubmed:author | pubmed-author:SheppardG SGS | lld:pubmed |
| pubmed-article:8027984 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8027984 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:8027984 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:8027984 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8027984 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:8027984 | pubmed:pagination | 2011-32 | lld:pubmed |
| pubmed-article:8027984 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:meshHeading | pubmed-meshheading:8027984-... | lld:pubmed |
| pubmed-article:8027984 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8027984 | pubmed:articleTitle | 3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists. | lld:pubmed |
| pubmed-article:8027984 | pubmed:affiliation | Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064. | lld:pubmed |
| pubmed-article:8027984 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8027984 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8027984 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:8027984 | lld:chembl |
