| pubmed-article:8023141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8023141 | lifeskim:mentions | umls-concept:C1327133 | lld:lifeskim |
| pubmed-article:8023141 | lifeskim:mentions | umls-concept:C0002520 | lld:lifeskim |
| pubmed-article:8023141 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:8023141 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:8023141 | lifeskim:mentions | umls-concept:C1518961 | lld:lifeskim |
| pubmed-article:8023141 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:8023141 | lifeskim:mentions | umls-concept:C0439828 | lld:lifeskim |
| pubmed-article:8023141 | pubmed:issue | 5169 | lld:pubmed |
| pubmed-article:8023141 | pubmed:dateCreated | 1994-8-2 | lld:pubmed |
| pubmed-article:8023141 | pubmed:abstractText | Monoclonal antibodies, induced with a phosphonate diester hapten, catalyzed the coupling of p-nitrophenyl esters of N-acetyl valine, leucine, and phenylalanine with tryptophan amide to form the corresponding dipeptides. All possible stereoisomeric combinations of the ester and amide substrates were coupled at comparable rates. The antibodies did not catalyze the hydrolysis of the dipeptide product nor hydrolysis or racemization of the activated esters. The yields of the dipeptides ranged from 44 to 94 percent. The antibodies were capable of multiple turnovers at rates that exceeded the rate of spontaneous ester hydrolysis. This achievement suggests routes toward creating a small number of antibody catalysts for polypeptide syntheses. | lld:pubmed |
| pubmed-article:8023141 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8023141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8023141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8023141 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8023141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8023141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8023141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8023141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8023141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8023141 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8023141 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:8023141 | pubmed:author | pubmed-author:HirschmannRR | lld:pubmed |
| pubmed-article:8023141 | pubmed:author | pubmed-author:BenkovicS JSJ | lld:pubmed |
| pubmed-article:8023141 | pubmed:author | pubmed-author:BenkovicP APA | lld:pubmed |
| pubmed-article:8023141 | pubmed:author | pubmed-author:TaylorC MCM | lld:pubmed |
| pubmed-article:8023141 | pubmed:author | pubmed-author:TaylorS DSD | lld:pubmed |
| pubmed-article:8023141 | pubmed:author | pubmed-author:SmithA BAB3rd | lld:pubmed |
| pubmed-article:8023141 | pubmed:author | pubmed-author:SprengelerP... | lld:pubmed |
| pubmed-article:8023141 | pubmed:author | pubmed-author:YagerK MKM | lld:pubmed |
| pubmed-article:8023141 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8023141 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:8023141 | pubmed:volume | 265 | lld:pubmed |
| pubmed-article:8023141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8023141 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8023141 | pubmed:pagination | 234-7 | lld:pubmed |
| pubmed-article:8023141 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8023141 | pubmed:meshHeading | pubmed-meshheading:8023141-... | lld:pubmed |
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| pubmed-article:8023141 | pubmed:meshHeading | pubmed-meshheading:8023141-... | lld:pubmed |
| pubmed-article:8023141 | pubmed:meshHeading | pubmed-meshheading:8023141-... | lld:pubmed |
| pubmed-article:8023141 | pubmed:meshHeading | pubmed-meshheading:8023141-... | lld:pubmed |
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| pubmed-article:8023141 | pubmed:meshHeading | pubmed-meshheading:8023141-... | lld:pubmed |
| pubmed-article:8023141 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8023141 | pubmed:articleTitle | Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids. | lld:pubmed |
| pubmed-article:8023141 | pubmed:affiliation | Department of Chemistry, University of Pennsylvania, Philadelphia 19104. | lld:pubmed |
| pubmed-article:8023141 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8023141 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8023141 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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