Linked Life Data

8012713

Source:http://linkedlifedata.com/resource/pubmed/id/8012713

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:8012713rdf:typepubmed:Citationlld:pubmed
pubmed-article:8012713lifeskim:mentionsumls-concept:C0999699lld:lifeskim
pubmed-article:8012713lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:8012713lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:8012713lifeskim:mentionsumls-concept:C2362924lld:lifeskim
pubmed-article:8012713lifeskim:mentionsumls-concept:C1327729lld:lifeskim
pubmed-article:8012713lifeskim:mentionsumls-concept:C0019564lld:lifeskim
pubmed-article:8012713lifeskim:mentionsumls-concept:C0003364lld:lifeskim
pubmed-article:8012713lifeskim:mentionsumls-concept:C0379900lld:lifeskim
pubmed-article:8012713lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:8012713lifeskim:mentionsumls-concept:C0443199lld:lifeskim
pubmed-article:8012713pubmed:issue1lld:pubmed
pubmed-article:8012713pubmed:dateCreated1994-7-25lld:pubmed
pubmed-article:8012713pubmed:abstractText1. The electrophysiological responses elicited by 5-hydroxytryptamine1A-(5-HT1A) receptor agonists in rat and guinea-pig CA1 pyramidal neurones and rat dorso-lateral septal neurones were compared in vitro by use of conventional intracellular recording techniques. 2. In the presence of 1 microM tetrodotoxin (TTX), to prevent indirect effects, 5-HT, N,N-dipropyl-5-carboxamidotryptamine (DP-5-CT) and 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT) hyperpolarized the neurones from rat and guinea-pig brain. 3. The hypotensive drug flesinoxan, a selective 5-HT1A receptor agonist, hyperpolarized neurones in all three areas tested; however, another hypotensive agent with high affinity at 5-HT1A-receptors, 5-methyl-urapidil, hyperpolarized only the neurones in rat hippocampus and septum. 4. In guinea-pig hippocampal neurones, 5-methyl-urapidil behaved as a 5-HT1A-receptor antagonist. 5. The relative efficacies (5-HT = 1) of DP-5-CT, 8-OH-DPAT, flesinoxan and 5-methyl-urapidil at the three sites were: rat hippocampus, 1.09, 0.7, 0.5 and 0.24; rat septum, 0.88, 0.69, 0.82 and 0.7; guinea-pig hippocampus, 1.0, 0.69, 0.89 and 0, respectively. 6. It is concluded that the hypotensive agents flesinoxan and 5-methyl-urapidil appear to have different efficacies at 5-HT1A receptors located in different regions of the rodent brain. Whether these regional and species differences arise from receptor plurality or variability in intracellular transduction mechanisms remains to be elucidated.lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:languageenglld:pubmed
pubmed-article:8012713pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:citationSubsetIMlld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8012713pubmed:statusMEDLINElld:pubmed
pubmed-article:8012713pubmed:monthJanlld:pubmed
pubmed-article:8012713pubmed:issn0007-1188lld:pubmed
pubmed-article:8012713pubmed:authorpubmed-author:GalvanMMlld:pubmed
pubmed-article:8012713pubmed:authorpubmed-author:BoeijingaP...lld:pubmed
pubmed-article:8012713pubmed:authorpubmed-author:LeishmanD JDJlld:pubmed
pubmed-article:8012713pubmed:issnTypePrintlld:pubmed
pubmed-article:8012713pubmed:volume111lld:pubmed
pubmed-article:8012713pubmed:ownerNLMlld:pubmed
pubmed-article:8012713pubmed:authorsCompleteYlld:pubmed
pubmed-article:8012713pubmed:pagination318-24lld:pubmed
pubmed-article:8012713pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:meshHeadingpubmed-meshheading:8012713-...lld:pubmed
pubmed-article:8012713pubmed:year1994lld:pubmed
pubmed-article:8012713pubmed:articleTitleDifferential effects of centrally-active antihypertensives on 5-HT1A receptors in rat dorso-lateral septum, rat hippocampus and guinea-pig hippocampus.lld:pubmed
pubmed-article:8012713pubmed:affiliationMarion Merrell Dow Research Institute, Strasbourg, France.lld:pubmed
pubmed-article:8012713pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8012713pubmed:publicationTypeComparative Studylld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:8012713lld:pubmed