| pubmed-article:8005749 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8005749 | lifeskim:mentions | umls-concept:C0023610 | lld:lifeskim |
| pubmed-article:8005749 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:8005749 | lifeskim:mentions | umls-concept:C0209366 | lld:lifeskim |
| pubmed-article:8005749 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:8005749 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:8005749 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8005749 | pubmed:dateCreated | 1994-7-19 | lld:pubmed |
| pubmed-article:8005749 | pubmed:abstractText | The new decapeptide SB-75 (INN: Cetrorelix) has been characterized as a potent antagonist of luteinizing-hormone releasing hormone (LH-RH). Such derivatives are of great medicinal interest owing to their potential application in areas such as hormone-dependent tumors, uterine fibroids, and in diseases and conditions which result from inappropriate hormone levels or which can be treated by suppression of estrogens. SB-75 is the subject of intensive ongoing clinical evaluation and is an accepted standard for the design of new LH-RH antagonists. We characterized SB-75 by means of modern MS and NMR techniques to demonstrate the significance of both sequencing methods on a complicated unnatural decapeptide. Our structural elucidations with nuclear Overhauser (NOE) experiments revealed clear evidence for a highly flexible molecule with no single predominant conformation even in sodium dodecyl sulfate (SDS) mimicking a cellular membrane. | lld:pubmed |
| pubmed-article:8005749 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8005749 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8005749 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8005749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8005749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8005749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8005749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8005749 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8005749 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8005749 | pubmed:issn | 0367-8377 | lld:pubmed |
| pubmed-article:8005749 | pubmed:author | pubmed-author:SchallyA VAV | lld:pubmed |
| pubmed-article:8005749 | pubmed:author | pubmed-author:EngelJJ | lld:pubmed |
| pubmed-article:8005749 | pubmed:author | pubmed-author:MüllerAA | lld:pubmed |
| pubmed-article:8005749 | pubmed:author | pubmed-author:KutscherBB | lld:pubmed |
| pubmed-article:8005749 | pubmed:author | pubmed-author:BuskerEE | lld:pubmed |
| pubmed-article:8005749 | pubmed:author | pubmed-author:BernaJJ | lld:pubmed |
| pubmed-article:8005749 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8005749 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:8005749 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8005749 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8005749 | pubmed:pagination | 264-70 | lld:pubmed |
| pubmed-article:8005749 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8005749 | pubmed:meshHeading | pubmed-meshheading:8005749-... | lld:pubmed |
| pubmed-article:8005749 | pubmed:meshHeading | pubmed-meshheading:8005749-... | lld:pubmed |
| pubmed-article:8005749 | pubmed:meshHeading | pubmed-meshheading:8005749-... | lld:pubmed |
| pubmed-article:8005749 | pubmed:meshHeading | pubmed-meshheading:8005749-... | lld:pubmed |
| pubmed-article:8005749 | pubmed:meshHeading | pubmed-meshheading:8005749-... | lld:pubmed |
| pubmed-article:8005749 | pubmed:meshHeading | pubmed-meshheading:8005749-... | lld:pubmed |
| pubmed-article:8005749 | pubmed:meshHeading | pubmed-meshheading:8005749-... | lld:pubmed |
| pubmed-article:8005749 | pubmed:meshHeading | pubmed-meshheading:8005749-... | lld:pubmed |
| pubmed-article:8005749 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8005749 | pubmed:articleTitle | Structural investigation of Cetrorelix, a new potent and long-acting LH-RH antagonist. | lld:pubmed |
| pubmed-article:8005749 | pubmed:affiliation | Degussa AG, Hanau-Wolfgang, Germany. | lld:pubmed |
| pubmed-article:8005749 | pubmed:publicationType | Journal Article | lld:pubmed |
