| pubmed-article:8003022 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8003022 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:8003022 | lifeskim:mentions | umls-concept:C0019630 | lld:lifeskim |
| pubmed-article:8003022 | lifeskim:mentions | umls-concept:C0063710 | lld:lifeskim |
| pubmed-article:8003022 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8003022 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8003022 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:8003022 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8003022 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8003022 | pubmed:dateCreated | 1994-7-14 | lld:pubmed |
| pubmed-article:8003022 | pubmed:abstractText | Activation of human monocytes or human monocytic cell lines by several types of stimuli coordinately induces IL-1 beta and its antagonist (IL-1Ra) gene expression; alterations in their balance seem to mediate the inflammatory response. Using the human monocytic cell line THP-1, we report that superantigens, such as staphylococcal enterotoxin A (SEA) and Mycoplasma arthritidis -derived superantigen (MAM) induce an increase in the level of IL-1 beta mRNA without any detectable effect on IL-Ra mRNA. Unlike MAM-induced IL-1 beta mRNA, SEA-induced IL-1 beta mRNA was adequately translated into protein. Superantigen-induced gene expression is mediated by signalling, via their receptors, the MHC class II molecules. Thus, it appears that this mode of signalling selectively induces the proinflammatory cytokine IL-1 beta gene expression which, by itself, can have major importance in disease pathology especially in autoimmune diseases. | lld:pubmed |
| pubmed-article:8003022 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8003022 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8003022 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8003022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8003022 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8003022 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8003022 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8003022 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:8003022 | pubmed:author | pubmed-author:al-DaccakRR | lld:pubmed |
| pubmed-article:8003022 | pubmed:author | pubmed-author:MouradWW | lld:pubmed |
| pubmed-article:8003022 | pubmed:author | pubmed-author:PoubelleP EPE | lld:pubmed |
| pubmed-article:8003022 | pubmed:author | pubmed-author:MehindateKK | lld:pubmed |
| pubmed-article:8003022 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8003022 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8003022 | pubmed:volume | 201 | lld:pubmed |
| pubmed-article:8003022 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8003022 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8003022 | pubmed:pagination | 855-60 | lld:pubmed |
| pubmed-article:8003022 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:8003022 | pubmed:meshHeading | pubmed-meshheading:8003022-... | lld:pubmed |
| pubmed-article:8003022 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8003022 | pubmed:articleTitle | Signalling via MHC class II molecules selectively induces IL-1 beta over IL-1 receptor antagonist gene expression. | lld:pubmed |
| pubmed-article:8003022 | pubmed:affiliation | Department of Medicine, Université Laval, St-Foy, Québec, Canada. | lld:pubmed |
| pubmed-article:8003022 | pubmed:publicationType | Journal Article | lld:pubmed |
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