| pubmed-article:8002552 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8002552 | lifeskim:mentions | umls-concept:C0162429 | lld:lifeskim |
| pubmed-article:8002552 | lifeskim:mentions | umls-concept:C0011980 | lld:lifeskim |
| pubmed-article:8002552 | lifeskim:mentions | umls-concept:C0034067 | lld:lifeskim |
| pubmed-article:8002552 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8002552 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8002552 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8002552 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8002552 | pubmed:dateCreated | 1995-1-20 | lld:pubmed |
| pubmed-article:8002552 | pubmed:abstractText | Interactive effects of emphysema (EMP) and prolonged nutritional deprivation (ND) on contractile, morphometric, and metabolic properties of hamster diaphragm muscle (DIA) were examined. Six months after induction of EMP (intratracheal elastase), saline-treated controls (CTL) and EMP hamsters of similar body weights were subjected to ND over 6 wk. Isometric contractile and fatigue properties of costal DIA were determined in vitro. DIA fibers were histochemically classified as type I or II, and fiber succinate dehydrogenase activity and cross-sectional area were determined using quantitative microscopic procedures. From histochemical sections, the number of capillaries per fiber (C/F) and per fiber cross-sectional area (C/A) were determined. ND resulted in progressive loss of body weight (ND-CTL, 23.8%; ND-EMP, 28.4%; P = NS). ND did not affect reduction in optimal length (Lo) of DIA fibers in EMP compared with CTL and ND-CTL hamsters. Maximum specific force (i.e., force/unit area) was reduced by approximately 25% in EMP animals compared with CTL. ND did not improve or exacerbate the reduction in specific force with EMP. ND attenuated improved fatigue resistance of DIA in EMP animals. No differences in fiber type proportions were noted among experimental groups. Significant atrophy of type I and II DIA fibers was noted after ND. Atrophy was proportionately greater in type II fibers of ND-EMP when referenced to EMP animals. Thus adaptive hypertrophy of type II DIA fibers in EMP animals was abolished. Fiber succinate dehydrogenase activity was significantly increased in type I and II fibers in EMP DIA. ND did not affect this metabolic adaptation of DIA fibers to persistent loads imposed by EMP.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:8002552 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8002552 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8002552 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8002552 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8002552 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8002552 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8002552 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8002552 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8002552 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8002552 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:8002552 | pubmed:author | pubmed-author:SieckG CGC | lld:pubmed |
| pubmed-article:8002552 | pubmed:author | pubmed-author:LewisM IMI | lld:pubmed |
| pubmed-article:8002552 | pubmed:author | pubmed-author:MonnS ASA | lld:pubmed |
| pubmed-article:8002552 | pubmed:author | pubmed-author:ZhanW ZWZ | lld:pubmed |
| pubmed-article:8002552 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8002552 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:8002552 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8002552 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8002552 | pubmed:pagination | 947-55 | lld:pubmed |
| pubmed-article:8002552 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:meshHeading | pubmed-meshheading:8002552-... | lld:pubmed |
| pubmed-article:8002552 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8002552 | pubmed:articleTitle | Interactive effects of emphysema and malnutrition on diaphragm structure and function. | lld:pubmed |
| pubmed-article:8002552 | pubmed:affiliation | Department of Medicine, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine 90048. | lld:pubmed |
| pubmed-article:8002552 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8002552 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8002552 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8002552 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8002552 | lld:pubmed |
