| pubmed-article:7996551 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7996551 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:7996551 | lifeskim:mentions | umls-concept:C0028005 | lld:lifeskim |
| pubmed-article:7996551 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:7996551 | lifeskim:mentions | umls-concept:C2757014 | lld:lifeskim |
| pubmed-article:7996551 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:7996551 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7996551 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:7996551 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7996551 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:7996551 | pubmed:dateCreated | 1995-1-13 | lld:pubmed |
| pubmed-article:7996551 | pubmed:abstractText | Conformational features of nicardipine in acetonitrile, in the absence and presence of Ca2+, were investigated by one-dimensional NMR and difference absorption spectroscopy techniques. The data show that in acetonitrile solution the antiperiplanar form of nicardipine is dominant. The addition of Ca2+ to the drug solution caused marked changes in the difference absorbance spectra in the 200-400 nm region and in many of its 1H and 13C NMR resonances. The changes were most significant up to a ratio of 0.5 Ca2+:drug. Analysis of the binding data showed the predominant species to be a 2:1 drug:Ca2+ "sandwich" complex with an estimated dissociation constant of 100 microM at 25 degrees C. One-dimensional nuclear Overhauser effect (NOE) experiments revealed through-space connectivities in the drug before and after Ca2+ binding. These changes in conjunction with the changes in 1H and 13C chemical shifts suggest a structure in which the 4-aryl ring substitute of the pyridine moiety moves closer to the C3-side chain in the presence of Ca2+. This attraction is achieved via the chelation of the Ca2+ ion by the oxygen atoms in the m-NO2 of the aryl group and the COOCH2 group in the side chain of the dihydropyridine ring, and gives rise to a stable synperiplanar conformation. A preference for this conformation was also observed in the Ca2+ complex of nifedipine in acetonitrile as inferred from the rather limited NOE data obtained. Our study provides a detailed solution structure for nicardipine and also leads to a suggestion of a role for Ca2+ in the action of this and possibly other dihydropyridines. | lld:pubmed |
| pubmed-article:7996551 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7996551 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7996551 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7996551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7996551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7996551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7996551 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7996551 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7996551 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7996551 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:7996551 | pubmed:author | pubmed-author:Ananthanaraya... | lld:pubmed |
| pubmed-article:7996551 | pubmed:author | pubmed-author:BelciugM PMP | lld:pubmed |
| pubmed-article:7996551 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7996551 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:7996551 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:7996551 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7996551 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7996551 | pubmed:pagination | 4392-9 | lld:pubmed |
| pubmed-article:7996551 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:meshHeading | pubmed-meshheading:7996551-... | lld:pubmed |
| pubmed-article:7996551 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7996551 | pubmed:articleTitle | Interaction of calcium channel antagonists with calcium: structural studies on nicardipine and its Ca2+ complex. | lld:pubmed |
| pubmed-article:7996551 | pubmed:affiliation | Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada. | lld:pubmed |
| pubmed-article:7996551 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7996551 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:7996551 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7996551 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7996551 | lld:pubmed |
