| pubmed-article:7992554 | pubmed:abstractText | The nuclear DNA content of 26 liver tumors (1 adenoma, 10 focal nodular hyperplasia and 15 hepatocellular carcinoma) was measured by flow cytometry (FCM) on formalin-fixed, paraffin-embedded tissues. All lesions developed in noncirrhotic liver and were negative for HBsAg. DNA aneuploidy was found in 1/10 FNH (one hypodiploid) and in 11/15 HCC (73%). Intratumoral heterogeneity was observed in three cases. In HCC the ploidy level showed no correlation with tumor size or histopathological grading. Results support the potential of FCM to measure DNA content in archival pathological specimens, and also that DNA content itself has no diagnostic value. | lld:pubmed |
