| pubmed-article:7989587 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C0063717 | lld:lifeskim |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:7989587 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:7989587 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7989587 | pubmed:dateCreated | 1995-1-6 | lld:pubmed |
| pubmed-article:7989587 | pubmed:abstractText | IL-6 is an autocrine growth factor for U266 myeloma cells and their growth is inhibited by IFN-alpha or IL-6 mAb. We asked, therefore, whether IFN-alpha-induced growth inhibition involved IL-6. IFN-alpha and mAb against IL-6, the IL-6R alpha-(gp80) or beta-chain (gp130) potently inhibited U266 cells. Remarkably, this effect occurred despite IFN-alpha-augmented secretion of endogenous IL-6. However, examining the IL-6R revealed that IFN-alpha drastically curtailed expression of the IL-6R alpha- and beta-chain. This effect occurred on two different levels (protein and mRNA) and by two different mechanisms (directly and indirectly through IL-6). First, IFN-alpha, but not IL-6, greatly decreased gp80 and, to a lesser extent, gp130 mRNA levels which resulted in a loss of IL-6 binding sites. Second, IFN-alpha-induced IL-6 predominantly down-regulated membrane-bound gp130. IFN-alpha-mediated decrease of gp80 levels was not detected on IL-6-independent myeloma (RPMI 8226) or myeloid cells (U937). We conclude that IFN-alpha inhibited IL-6-dependent myeloma cell growth by depriving U266 cells of an essential component of their autocrine growth loop, a functional IL-6R. | lld:pubmed |
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| pubmed-article:7989587 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7989587 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7989587 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7989587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7989587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7989587 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7989587 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:7989587 | pubmed:author | pubmed-author:PrinclerG LGL | lld:pubmed |
| pubmed-article:7989587 | pubmed:author | pubmed-author:MARSP HPH | lld:pubmed |
| pubmed-article:7989587 | pubmed:author | pubmed-author:EgawaMM | lld:pubmed |
| pubmed-article:7989587 | pubmed:author | pubmed-author:RubboliFF | lld:pubmed |
| pubmed-article:7989587 | pubmed:author | pubmed-author:SchwabeMM | lld:pubmed |
| pubmed-article:7989587 | pubmed:author | pubmed-author:ZhaoJJ | lld:pubmed |
| pubmed-article:7989587 | pubmed:author | pubmed-author:BriniA TAT | lld:pubmed |
| pubmed-article:7989587 | pubmed:author | pubmed-author:BoscoM CMC | lld:pubmed |
| pubmed-article:7989587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7989587 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:7989587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7989587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7989587 | pubmed:pagination | 2317-25 | lld:pubmed |
| pubmed-article:7989587 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7989587 | pubmed:meshHeading | pubmed-meshheading:7989587-... | lld:pubmed |
| pubmed-article:7989587 | pubmed:meshHeading | pubmed-meshheading:7989587-... | lld:pubmed |
