| pubmed-article:7983003 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:7983003 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
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| pubmed-article:7983003 | lifeskim:mentions | umls-concept:C1424530 | lld:lifeskim |
| pubmed-article:7983003 | lifeskim:mentions | umls-concept:C0237497 | lld:lifeskim |
| pubmed-article:7983003 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:7983003 | lifeskim:mentions | umls-concept:C0185023 | lld:lifeskim |
| pubmed-article:7983003 | lifeskim:mentions | umls-concept:C1947904 | lld:lifeskim |
| pubmed-article:7983003 | lifeskim:mentions | umls-concept:C1999228 | lld:lifeskim |
| pubmed-article:7983003 | lifeskim:mentions | umls-concept:C2825781 | lld:lifeskim |
| pubmed-article:7983003 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7983003 | pubmed:issue | 49 | lld:pubmed |
| pubmed-article:7983003 | pubmed:dateCreated | 1995-1-4 | lld:pubmed |
| pubmed-article:7983003 | pubmed:abstractText | The nuclear factor kappa B, NF-kappa B, is activated by numerous inflammatory mediators, regulating biological responses that in part are dependent on the extracellular matrix. Analyses of the influence of cell-matrix interaction on NF-kappa B activation revealed that attachment to fibronectin caused an increase in NF-kappa B activity corresponding to 3-fold the level in cells plated on bare plastic. This effect was dependent on the degree of attachment and appeared to involve both the RGD motif of the cell-binding domain, and the heparin-binding domain of fibronectin. Fibronectin attachment specifically caused activation of the p50/p65 heterodimeric form of NF-kappa B, resulting in an increase of this complex to a level similar to that induced by cytokine stimulation. These data show that cell attachment has a pronounced influence on the level of NF-kappa B activity, affecting specific dimeric complexes, and suggest this to be a pathway through which effects depending on cell-matrix interaction can regulate cell behavior and cytokine responses. | lld:pubmed |
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| pubmed-article:7983003 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7983003 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7983003 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7983003 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7983003 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7983003 | pubmed:author | pubmed-author:RichardsonC... | lld:pubmed |
| pubmed-article:7983003 | pubmed:author | pubmed-author:BomsztykKK | lld:pubmed |
| pubmed-article:7983003 | pubmed:author | pubmed-author:QwarnströmE... | lld:pubmed |
| pubmed-article:7983003 | pubmed:author | pubmed-author:OstbergC OCO | lld:pubmed |
| pubmed-article:7983003 | pubmed:author | pubmed-author:TurkG LGL | lld:pubmed |
| pubmed-article:7983003 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7983003 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:7983003 | pubmed:volume | 269 | lld:pubmed |
| pubmed-article:7983003 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7983003 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7983003 | pubmed:pagination | 30765-8 | lld:pubmed |
| pubmed-article:7983003 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7983003 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7983003 | pubmed:articleTitle | Fibronectin attachment activates the NF-kappa B p50/p65 heterodimer in fibroblasts and smooth muscle cells. | lld:pubmed |
| pubmed-article:7983003 | pubmed:affiliation | Department of Pathology, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:7983003 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7983003 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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