| pubmed-article:7980446 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7980446 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7980446 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7980446 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:7980446 | lifeskim:mentions | umls-concept:C1709708 | lld:lifeskim |
| pubmed-article:7980446 | lifeskim:mentions | umls-concept:C0072034 | lld:lifeskim |
| pubmed-article:7980446 | pubmed:dateCreated | 1994-12-20 | lld:pubmed |
| pubmed-article:7980446 | pubmed:abstractText | The proform of cathepsin D is secreted by some human breast-cancer cell lines upon stimulation with oestrogen. In these cell lines, procathepsin D was described to act as an autocrine mitogen, and a correlation between the cathepsin D concentration in tumour tissues and poor prognosis for the patient was demonstrated in several independent investigations. In the present study, we focused on the mechanism of procathepsin D mitogenic activity. Procathepsin D isolated from secretions of ZR-75-1 breast-cancer cell line was used to test for mitogenic activity on a set of seven human cell lines. For nanomolar procathepsin D concentrations, we found a stronger dose-responsive cellular reaction in the case of several different human breast-cancer-derived cell lines. The mitogenic activity was not blocked by the inhibition of proteolytic activity nor by the inhibition of the interaction of procathepsin D with mannose-6-phosphate receptors. On the other hand, the addition of antibodies raised against the propeptide impaired the mitogenic activity of procathepsin D, and a synthetic peptide alone corresponding to the propeptide of procathepsin D produced similar effects, as did the zymogen molecule. The synthetic propeptide was shown to block partially the interaction of procathepsin D with the cellular surface. Our results indicate that the mitogenic function involves the propeptide of cathepsin D, which appears to be recognized by a surface receptor. | lld:pubmed |
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| pubmed-article:7980446 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7980446 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7980446 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7980446 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7980446 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7980446 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:7980446 | pubmed:author | pubmed-author:FusekMM | lld:pubmed |
| pubmed-article:7980446 | pubmed:author | pubmed-author:VetvickaVV | lld:pubmed |
| pubmed-article:7980446 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7980446 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7980446 | pubmed:volume | 303 ( Pt 3) | lld:pubmed |
| pubmed-article:7980446 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7980446 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7980446 | pubmed:pagination | 775-80 | lld:pubmed |
| pubmed-article:7980446 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7980446 | pubmed:meshHeading | pubmed-meshheading:7980446-... | lld:pubmed |
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| pubmed-article:7980446 | pubmed:meshHeading | pubmed-meshheading:7980446-... | lld:pubmed |
| pubmed-article:7980446 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7980446 | pubmed:articleTitle | Mitogenic function of human procathepsin D: the role of the propeptide. | lld:pubmed |
| pubmed-article:7980446 | pubmed:affiliation | Oklahoma Medical Research Foundation, Oklahoma City 73104. | lld:pubmed |
| pubmed-article:7980446 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7980446 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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