| pubmed-article:7979365 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7979365 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:7979365 | lifeskim:mentions | umls-concept:C1420876 | lld:lifeskim |
| pubmed-article:7979365 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:7979365 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:7979365 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7979365 | pubmed:dateCreated | 1994-12-7 | lld:pubmed |
| pubmed-article:7979365 | pubmed:abstractText | Tripeptidyl peptidase II is an intracellular exopeptidase, which has been purified from rat liver and human erythrocytes. An efficient specific inhibitor was obtained through beta-elimination of phosphate from the phosphopeptide Arg-Ala-Ser(P)-Val-Ala. The dehydroalanine-containing peptide formed was a competitive inhibitor with a Ki of 0.02 +/- 0.01 microM. This study demonstrated that replacing a serine residue in a good inhibitor with a dehydroalanine residue reduced the Ki 45 times. It is proposed that dehydroalanine-containing peptides could be of interest in the development of inhibitors for other peptidases as well. | lld:pubmed |
| pubmed-article:7979365 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7979365 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7979365 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7979365 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7979365 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7979365 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7979365 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:7979365 | pubmed:author | pubmed-author:FranssonBB | lld:pubmed |
| pubmed-article:7979365 | pubmed:author | pubmed-author:ZetterqvistOO | lld:pubmed |
| pubmed-article:7979365 | pubmed:author | pubmed-author:TomkinsonBB | lld:pubmed |
| pubmed-article:7979365 | pubmed:author | pubmed-author:GrehnLL | lld:pubmed |
| pubmed-article:7979365 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7979365 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7979365 | pubmed:volume | 314 | lld:pubmed |
| pubmed-article:7979365 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7979365 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7979365 | pubmed:pagination | 276-9 | lld:pubmed |
| pubmed-article:7979365 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7979365 | pubmed:meshHeading | pubmed-meshheading:7979365-... | lld:pubmed |
| pubmed-article:7979365 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7979365 | pubmed:articleTitle | Use of a dehydroalanine-containing peptide as an efficient inhibitor of tripeptidyl peptidase II. | lld:pubmed |
| pubmed-article:7979365 | pubmed:affiliation | Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, Uppsala. | lld:pubmed |
| pubmed-article:7979365 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7979365 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7979365 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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