| pubmed-article:797286 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:797286 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:797286 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:797286 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:797286 | lifeskim:mentions | umls-concept:C1368474 | lld:lifeskim |
| pubmed-article:797286 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:797286 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:797286 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:797286 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:797286 | pubmed:dateCreated | 1977-3-15 | lld:pubmed |
| pubmed-article:797286 | pubmed:abstractText | This study has tested the ability of human mononuclear cells and the subpopulations of lymphocytes that rosette (E-RFC) or do not rosette (non-E-RFC) with sheep red blood cells to synthesize DNA and to produce a mediator with bone resorbing activity (osteoclast-activating factor, OAF) in response to stimulation with phytohemagglutinin (PHA). Mononuclear cells were stimulated by PHA both to synthesize DNA and to produce a factor that caused bone resorption. E-RFC enriched for T lymphocytes and depleted of macrophages synthesized considerable DNA in response to stimulation with PHA, but were unable to produce significant bone resorbing activity in tissue culture unless macrophages were re-added to the E-RFC. In contrast, mononuclear cells depleted of E-RFC (non-E-RFC enriched for B cells) did not synthesize DNA in response to stimulation with PHA, but did produce a mediator that caused significant bone resorption in tissue culture. In most of the experiments, unstimulated non-E-RFC produced as much OAF as the PHA-stimulated non-E-RFC. These results suggest that both activated T lymphocytes (E-RFC) and B lymphocytes (non-E-RFC) can produce OAF. | lld:pubmed |
| pubmed-article:797286 | pubmed:language | eng | lld:pubmed |
| pubmed-article:797286 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:797286 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:797286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:797286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:797286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:797286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:797286 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:797286 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:797286 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:797286 | pubmed:author | pubmed-author:OppenheimJ... | lld:pubmed |
| pubmed-article:797286 | pubmed:author | pubmed-author:HortonJJ | lld:pubmed |
| pubmed-article:797286 | pubmed:author | pubmed-author:BakerJ JJJ | lld:pubmed |
| pubmed-article:797286 | pubmed:author | pubmed-author:ChenPP | lld:pubmed |
| pubmed-article:797286 | pubmed:author | pubmed-author:TrummelCC | lld:pubmed |
| pubmed-article:797286 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:797286 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:797286 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:797286 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:797286 | pubmed:pagination | 732-6 | lld:pubmed |
| pubmed-article:797286 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:797286 | pubmed:meshHeading | pubmed-meshheading:797286-H... | lld:pubmed |
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| pubmed-article:797286 | pubmed:meshHeading | pubmed-meshheading:797286-L... | lld:pubmed |
| pubmed-article:797286 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:797286 | pubmed:articleTitle | Production of osteoclast-activating factor by normal human peripheral blood rosetting and nonrosetting lymphocytes. | lld:pubmed |
| pubmed-article:797286 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:797286 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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