| pubmed-article:7972086 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0019630 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0019776 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C1854494 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C1422006 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:7972086 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7972086 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:7972086 | pubmed:dateCreated | 1994-12-27 | lld:pubmed |
| pubmed-article:7972086 | pubmed:abstractText | Either of two structurally related major histocompatibility complex class II alleles, DRB1*1102, which encodes a DR5 specificity, or DRB1*1301, which encodes a DR6 specificity, was found in 67% of individuals responding to human immunodeficiency virus type 1 (HIV-1) infection with a syndrome characterized by persistent circulating and diffusely infiltrative CD8 lymphocytosis (DILS), slow progression to opportunistic infections, and delayed CD4 T-cell depletion. These alleles were present in only 28% of ethnically matched HIV-positive controls (P = 0.001). The frequency of DRB1*1301 was increased in both Blacks and Caucasians with this syndrome, while that of DRBI*1102 was increased only in Blacks, where 80% had either of these alleles. To investigate whether the host response associated with these alleles influences the evolutionary divergence of the HIV-1 genome, sequencing of the envelope V3 loop was performed. This revealed a significantly diminished lymphocyte viral heterogeneity compared with random HIV+ controls matched for CD4 T-cell levels. These results suggest that the immunogenetics of the host influence the nature of the immune response to HIV-1, which may lead to constrained evolution of HIV-1 gene products. Of possible relevance, the alpha-helical third diversity region common to both the DRB1*1102 and DRB1*1301 allelic products was noted to have homology with the C-terminal region of the HIV-1 envelope V3 loop at six of nine consecutive residues. This suggests the possibility that these alleles may bias the anti-HIV T-cell receptor repertoire through a mimicry mechanism. | lld:pubmed |
| pubmed-article:7972086 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7972086 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7972086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7972086 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7972086 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7972086 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7972086 | pubmed:author | pubmed-author:RossAA | lld:pubmed |
| pubmed-article:7972086 | pubmed:author | pubmed-author:WinchesterRR | lld:pubmed |
| pubmed-article:7972086 | pubmed:author | pubmed-author:DwyerEE | lld:pubmed |
| pubmed-article:7972086 | pubmed:author | pubmed-author:ItescuSS | lld:pubmed |
| pubmed-article:7972086 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7972086 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:7972086 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:7972086 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7972086 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7972086 | pubmed:pagination | 11472-6 | lld:pubmed |
| pubmed-article:7972086 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:meshHeading | pubmed-meshheading:7972086-... | lld:pubmed |
| pubmed-article:7972086 | pubmed:year | 1994 | lld:pubmed |
