| pubmed-article:7969150 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7969150 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:7969150 | lifeskim:mentions | umls-concept:C0002270 | lld:lifeskim |
| pubmed-article:7969150 | lifeskim:mentions | umls-concept:C1257757 | lld:lifeskim |
| pubmed-article:7969150 | lifeskim:mentions | umls-concept:C1516960 | lld:lifeskim |
| pubmed-article:7969150 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:7969150 | pubmed:dateCreated | 1994-12-20 | lld:pubmed |
| pubmed-article:7969150 | pubmed:abstractText | Although globin mRNAs are considered prototypes of highly stable messages, the mechanisms responsible for their longevity remain largely undefined. As an initial step in identifying potential cis-acting elements or structures which contribute to their stability, we analyzed the defect in expression of a naturally occurring alpha 2-globin mutant, alpha Constant Spring (CS). The CS mutation is a single-base change in the translation termination codon (UAA-->CAA) that allows the ribosome to read through into the 3' nontranslated region (NTR). The presence of CS mRNA in transcriptionally active erythroid precursors and its absence (relative to normal alpha-globin mRNA) in the more differentiated transcriptionally silent erythrocytes suggest that this mutation disrupts some feature of the alpha-globin mRNA required for its stability. Using a transient transfection system, we demonstrate that in murine erythroleukemia cells the CS mRNA is unstable compared with the normal alpha 2-globin mRNA. The analyses of several other naturally occurring and site-directed mutant alpha-globin genes in murine erythroleukemia cells indicate that entry of a translating ribosome into the 3' NTR targets the message for accelerated degradation in erythroid cells. In contrast, both the CS and alpha 2-globin mRNAs are stable in several nonerythroid cell lines. These results suggest that translational readthrough disrupts a determinant associated with the alpha 2-globin 3' NTR which is required for mRNA stability in erythroid cells. | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7969150 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7969150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969150 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7969150 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7969150 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:7969150 | pubmed:author | pubmed-author:LiebhaberS... | lld:pubmed |
| pubmed-article:7969150 | pubmed:author | pubmed-author:WeissI MIM | lld:pubmed |
| pubmed-article:7969150 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7969150 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:7969150 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7969150 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7969150 | pubmed:pagination | 8123-32 | lld:pubmed |
| pubmed-article:7969150 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:meshHeading | pubmed-meshheading:7969150-... | lld:pubmed |
| pubmed-article:7969150 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7969150 | pubmed:articleTitle | Erythroid cell-specific determinants of alpha-globin mRNA stability. | lld:pubmed |
