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| pubmed-article:7964503 | lifeskim:mentions | umls-concept:C0919490 | lld:lifeskim |
| pubmed-article:7964503 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7964503 | lifeskim:mentions | umls-concept:C0072473 | lld:lifeskim |
| pubmed-article:7964503 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7964503 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:7964503 | lifeskim:mentions | umls-concept:C0033713 | lld:lifeskim |
| pubmed-article:7964503 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:7964503 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:7964503 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:7964503 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7964503 | pubmed:dateCreated | 1994-12-23 | lld:pubmed |
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| pubmed-article:7964503 | pubmed:abstractText | The receptor for macrophage colony stimulating factor (CSF-1), the c-fms gene product, is a key determinant in the differentiation of monocytic phagocytes. Dissection of the human and mouse c-fms proximal promoters revealed opposing roles for nuclear protooncogenes in the transcriptional regulation of this gene. On the one hand, c-ets-1, c-ets-2, and the macrophage-specific factor PU.1, but not the ets-factor PEA3, trans-activated the c-fms proximal promoter. On the other hand c-myb repressed proximal promoter activity in macrophages and blocked the action of c-ets-1 and c-ets-2. Basal c-fms promoter activity was almost undetectable in the M1 leukaemia line, which expressed high levels of c-myb, but was activated as cells differentiated in response to leukemia inhibitory factor and expressed c-fms mRNA. The repressor function of c-myb depended on the COOH-terminal domain of the protein. We propose that ets-factors are necessary for the tissue-restricted expression of c-fms and that c-myb acts to ensure correct temporal expression of c-fms during myeloid differentiation. | lld:pubmed |
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| pubmed-article:7964503 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7964503 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7964503 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7964503 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7964503 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7964503 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:7964503 | pubmed:author | pubmed-author:YuuHH | lld:pubmed |
| pubmed-article:7964503 | pubmed:author | pubmed-author:HumeD ADA | lld:pubmed |
| pubmed-article:7964503 | pubmed:author | pubmed-author:BarnettC JCJ | lld:pubmed |
| pubmed-article:7964503 | pubmed:author | pubmed-author:OstrowskiM... | lld:pubmed |
| pubmed-article:7964503 | pubmed:author | pubmed-author:ReddyM AMA | lld:pubmed |
| pubmed-article:7964503 | pubmed:author | pubmed-author:YangB SBS | lld:pubmed |
| pubmed-article:7964503 | pubmed:author | pubmed-author:RossI LIL | lld:pubmed |
| pubmed-article:7964503 | pubmed:author | pubmed-author:SweetM JMJ | lld:pubmed |
| pubmed-article:7964503 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7964503 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7964503 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:7964503 | pubmed:geneSymbol | c-fms | lld:pubmed |
| pubmed-article:7964503 | pubmed:geneSymbol | c-myb | lld:pubmed |
| pubmed-article:7964503 | pubmed:geneSymbol | c-ets | lld:pubmed |
| pubmed-article:7964503 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7964503 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7964503 | pubmed:pagination | 2309-19 | lld:pubmed |
| pubmed-article:7964503 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:7964503 | pubmed:meshHeading | pubmed-meshheading:7964503-... | lld:pubmed |
| pubmed-article:7964503 | pubmed:meshHeading | pubmed-meshheading:7964503-... | lld:pubmed |
