Linked Life Data

7963517

Source:http://linkedlifedata.com/resource/pubmed/id/7963517

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:7963517rdf:typepubmed:Citationlld:pubmed
pubmed-article:7963517lifeskim:mentionsumls-concept:C0025914lld:lifeskim
pubmed-article:7963517lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:7963517lifeskim:mentionsumls-concept:C0039194lld:lifeskim
pubmed-article:7963517lifeskim:mentionsumls-concept:C0009015lld:lifeskim
pubmed-article:7963517lifeskim:mentionsumls-concept:C0288331lld:lifeskim
pubmed-article:7963517lifeskim:mentionsumls-concept:C1521991lld:lifeskim
pubmed-article:7963517lifeskim:mentionsumls-concept:C1332397lld:lifeskim
pubmed-article:7963517lifeskim:mentionsumls-concept:C1880022lld:lifeskim
pubmed-article:7963517pubmed:issue10lld:pubmed
pubmed-article:7963517pubmed:dateCreated1994-12-7lld:pubmed
pubmed-article:7963517pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:abstractTextWe report the cloning and initial characterization of the mouse homologues of the bcl-2-related gene, bcl-x. We compare these to the two major isoforms of human bcl-x that were previously identified, bcl-xLong (bcl-xL) which has death repressor activity similar to bcl-2, and bcl-xShort (bcl-xS), an alternative mRNA splice product that deletes a highly conserved domain shared by bcl-2 family members and promotes cell death in transfection studies. In addition to murine (m) bcl-xL and mbcl-xS, we have cloned a novel cDNA isoform that we designate mbcl-x delta TM. This cDNA deletes, by means of alternative splicing, the carboxy terminal transmembrane domain of bcl-x and is predicted to be a soluble, rather than membrane-bound, protein. We found that mbcl-x mRNA is highly inducible in splenocytes stimulated with either anti-CD3 Abs or LPS/dextran sulfate, and that the major species of mbcl-x mRNA in a variety of cell lines and tissues was the xL isoform. Transfection of mbcl-xL or mbcl-xS into Hela cells resulted in targeting primarily to mitochondria, whereas mbcl-x delta TM localized diffusely throughout the cytosol. Overexpression of the novel delta TM isoform in an IL-3-dependent cell line delayed the onset of apoptosis induced by growth factor withdrawal. Thus, a naturally-occurring form of mbcl-x present in lymphocytes that does not localize to the mitochondrial membrane is functional in preventing apoptotic cell death. Moreover, these data suggest that bcl-x provides a life signal in activated lymphocytes.lld:pubmed
pubmed-article:7963517pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:languageenglld:pubmed
pubmed-article:7963517pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:citationSubsetAIMlld:pubmed
pubmed-article:7963517pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7963517pubmed:statusMEDLINElld:pubmed
pubmed-article:7963517pubmed:monthNovlld:pubmed
pubmed-article:7963517pubmed:issn0022-1767lld:pubmed
pubmed-article:7963517pubmed:authorpubmed-author:MuellerD LDLlld:pubmed
pubmed-article:7963517pubmed:authorpubmed-author:DartL HLHJrlld:pubmed
pubmed-article:7963517pubmed:authorpubmed-author:BehrensT WTWlld:pubmed
pubmed-article:7963517pubmed:authorpubmed-author:RivardJ JJJlld:pubmed
pubmed-article:7963517pubmed:issnTypePrintlld:pubmed
pubmed-article:7963517pubmed:day15lld:pubmed
pubmed-article:7963517pubmed:volume153lld:pubmed
pubmed-article:7963517pubmed:geneSymbolbcl-xlld:pubmed
pubmed-article:7963517pubmed:ownerNLMlld:pubmed
pubmed-article:7963517pubmed:authorsCompleteYlld:pubmed
pubmed-article:7963517pubmed:pagination4388-98lld:pubmed
pubmed-article:7963517pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:meshHeadingpubmed-meshheading:7963517-...lld:pubmed
pubmed-article:7963517pubmed:year1994lld:pubmed
pubmed-article:7963517pubmed:articleTitleCloning and molecular characterization of mouse bcl-x in B and T lymphocytes.lld:pubmed
pubmed-article:7963517pubmed:affiliationDepartment of Medicine/Rheumatology, University of Minnesota, Minneapolis 55455.lld:pubmed
pubmed-article:7963517pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7963517pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:7963517pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:12048entrezgene:pubmedpubmed-article:7963517lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7963517lld:pubmed