| pubmed-article:7961904 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7961904 | lifeskim:mentions | umls-concept:C0206679 | lld:lifeskim |
| pubmed-article:7961904 | lifeskim:mentions | umls-concept:C0812382 | lld:lifeskim |
| pubmed-article:7961904 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:7961904 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:7961904 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:7961904 | lifeskim:mentions | umls-concept:C0439659 | lld:lifeskim |
| pubmed-article:7961904 | lifeskim:mentions | umls-concept:C1979975 | lld:lifeskim |
| pubmed-article:7961904 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:7961904 | pubmed:issue | 46 | lld:pubmed |
| pubmed-article:7961904 | pubmed:dateCreated | 1994-12-19 | lld:pubmed |
| pubmed-article:7961904 | pubmed:abstractText | The herpes simplex virus type 1 (HSV-1) origin binding protein (UL9 protein) interacts specifically with the HSV-1 encoded single strand DNA-binding protein ICP8 (Boehmer, P.E. and Lehman, I.R. (1994) Proc. Natl. Acad. Sci. U.S.A. 90, 8444-8448). A UL9 mutant protein (UL9DM27) that lacks the C-terminal 27 amino acids shows normal origin-specific DNA binding and retains its DNA-dependent ATPase and helicase activities, but has a greatly reduced affinity for ICP8. The extreme C-terminal portion of the UL9 protein is therefore required for ICP8 binding. The helicase activity of the UL9DM27 protein is approximately 8-fold greater than that of the wild type UL9 protein and is not stimulated by ICP8. The UL9DM27 protein has a reduced ability to replicate origin-containing plasmids in vivo. Consequently, the interaction between the UL9 protein and ICP8 is likely to be important for origin-dependent DNA replication in vivo, presumably to promote efficient unwinding of the DNA at an HSV-1 origin of DNA replication. | lld:pubmed |
| pubmed-article:7961904 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7961904 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7961904 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7961904 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7961904 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7961904 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7961904 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7961904 | pubmed:author | pubmed-author:LehmanI RIR | lld:pubmed |
| pubmed-article:7961904 | pubmed:author | pubmed-author:TJAYJ KJK | lld:pubmed |
| pubmed-article:7961904 | pubmed:author | pubmed-author:BoehmerP EPE | lld:pubmed |
| pubmed-article:7961904 | pubmed:author | pubmed-author:CraigieM CMC | lld:pubmed |
| pubmed-article:7961904 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7961904 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:7961904 | pubmed:volume | 269 | lld:pubmed |
| pubmed-article:7961904 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7961904 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7961904 | pubmed:pagination | 29329-34 | lld:pubmed |
| pubmed-article:7961904 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7961904 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7961904 | pubmed:articleTitle | Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo. | lld:pubmed |
| pubmed-article:7961904 | pubmed:affiliation | Department of Biochemistry, Beckman Center, Stanford University School of Medicine, California 94305. | lld:pubmed |
| pubmed-article:7961904 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7961904 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7961904 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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