| pubmed-article:7959905 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7959905 | lifeskim:mentions | umls-concept:C0439861 | lld:lifeskim |
| pubmed-article:7959905 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:7959905 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:7959905 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:7959905 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:7959905 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7959905 | pubmed:dateCreated | 1994-12-12 | lld:pubmed |
| pubmed-article:7959905 | pubmed:abstractText | Chemotactic activity of granulocytes attracted by tumor cells loaded either with anti-ganglioside monoclonal antibodies (mAb) or with antibody-glucose oxidase conjugates (mAb-GO) was investigated. The melanoma cell line SK-Mel-28 which expresses the ganglioside GD3 at high density as well as the neuroectodermal cell line SK-N-LO which expresses GD2 were used for the experiments. In the presence of 50% human AB-serum, antibody-loaded tumor cells induced chemotactic activity on granulocytes, probably due to the generation of C3a/C5a which could be detected in serum incubated with anti-GD3 loaded SK-Mel-28 cells. Both compounds could also be detected in vivo in the plasma of patients suffering from neuroblastoma during therapy with anti-GD2 antibodies. In another set of experiments mAb-GO conjugates generating high amounts of H2O2 in the presence of glucose were bound to these tumor cells. A significant lipid peroxidation could be observed in the simultaneous presence of iron and ascorbate. The lipid peroxidation products were measured as thiobarbituric acid-reactive substances (TBARS) and were also shown to induce chemotactic effects on granulocytes. | lld:pubmed |
| pubmed-article:7959905 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7959905 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7959905 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7959905 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7959905 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:7959905 | pubmed:author | pubmed-author:NiethammerDD | lld:pubmed |
| pubmed-article:7959905 | pubmed:author | pubmed-author:RassnerGG | lld:pubmed |
| pubmed-article:7959905 | pubmed:author | pubmed-author:MayerPP | lld:pubmed |
| pubmed-article:7959905 | pubmed:author | pubmed-author:BrucheltGG | lld:pubmed |
| pubmed-article:7959905 | pubmed:author | pubmed-author:FierlbeckGG | lld:pubmed |
| pubmed-article:7959905 | pubmed:author | pubmed-author:Handgretinger... | lld:pubmed |
| pubmed-article:7959905 | pubmed:author | pubmed-author:MeyleJJ | lld:pubmed |
| pubmed-article:7959905 | pubmed:author | pubmed-author:JeschkeBB | lld:pubmed |
| pubmed-article:7959905 | pubmed:author | pubmed-author:SchaberBB | lld:pubmed |
| pubmed-article:7959905 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7959905 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:7959905 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7959905 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7959905 | pubmed:pagination | 67-71 | lld:pubmed |
| pubmed-article:7959905 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7959905 | pubmed:meshHeading | pubmed-meshheading:7959905-... | lld:pubmed |
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| pubmed-article:7959905 | pubmed:meshHeading | pubmed-meshheading:7959905-... | lld:pubmed |
| pubmed-article:7959905 | pubmed:meshHeading | pubmed-meshheading:7959905-... | lld:pubmed |
| pubmed-article:7959905 | pubmed:meshHeading | pubmed-meshheading:7959905-... | lld:pubmed |
| pubmed-article:7959905 | pubmed:meshHeading | pubmed-meshheading:7959905-... | lld:pubmed |
| pubmed-article:7959905 | pubmed:meshHeading | pubmed-meshheading:7959905-... | lld:pubmed |
| pubmed-article:7959905 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7959905 | pubmed:articleTitle | Chemotactic activity of substances derived from antibody-loaded tumor cells on granulocytes. | lld:pubmed |
| pubmed-article:7959905 | pubmed:affiliation | Department of Dermatology, Children's Hospital, Tuebingen, Germany. | lld:pubmed |
| pubmed-article:7959905 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7959905 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
