| pubmed-article:7955905 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C0004388 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C0598012 | lld:lifeskim |
| pubmed-article:7955905 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:7955905 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7955905 | pubmed:dateCreated | 1994-12-12 | lld:pubmed |
| pubmed-article:7955905 | pubmed:abstractText | 1. Cardiac chronotropic responses to isoprenaline are reduced with ageing in man. It is unclear whether this is due to reduced cardiac beta-adrenergic sensitivity or to age-associated differences in reflex cardiovascular responses to the vasodilatory effects of isoprenaline. Age-associated changes in physical activity are also reported to influence beta-adrenergic sensitivity. 2. The aim of the present study was to determine the contribution of alterations in reflex changes in para-sympathetic and sympathetic influences and physical fitness to the age-associated reduction in cardiac chronotropic responses to beta-adrenergic agonists. 3. The effect of 'autonomic blockade' with atropine (40 micrograms/kg intravenously) and clonidine (4 micrograms/kg intravenously) on blood pressure, heart rate and chronotropic responses to intravenous bolus isoprenaline doses was determined in eight healthy young (mean age 21 years), nine healthy elderly (72 years) and 10 endurance-trained elderly (69 years) subjects. 4. Elderly subjects had a reduced increase in heart rate after atropine (young, 49 +/- 9 beats/min; elderly, 36 +/- 5 beats/min; endurance-trained elderly, 34 +/- 12 beats/min; P < 0.01) and did not demonstrate the transient increase in systolic blood pressure after clonidine observed in young subjects (young, 11 +/- 10 mmHg; elderly, -12 +/- 16 mmHg; endurance-trained elderly, -18 +/- 11 mmHg; P < 0.01). 5. Cardiac chronotropic sensitivity to isoprenaline after 'autonomic blockade' increased in the young but decreased in the elderly subjects.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:7955905 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7955905 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7955905 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7955905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7955905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7955905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7955905 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7955905 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7955905 | pubmed:issn | 0143-5221 | lld:pubmed |
| pubmed-article:7955905 | pubmed:author | pubmed-author:JamesO FOF | lld:pubmed |
| pubmed-article:7955905 | pubmed:author | pubmed-author:FordG AGA | lld:pubmed |
| pubmed-article:7955905 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7955905 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:7955905 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7955905 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7955905 | pubmed:pagination | 297-302 | lld:pubmed |
| pubmed-article:7955905 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7955905 | pubmed:meshHeading | pubmed-meshheading:7955905-... | lld:pubmed |
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| pubmed-article:7955905 | pubmed:meshHeading | pubmed-meshheading:7955905-... | lld:pubmed |
| pubmed-article:7955905 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7955905 | pubmed:articleTitle | Effect of 'autonomic blockade' on cardiac beta-adrenergic chronotropic responsiveness in healthy young, healthy elderly and endurance-trained elderly subjects. | lld:pubmed |
| pubmed-article:7955905 | pubmed:affiliation | Department of Medicine (Geriatrics), University of Newcastle-upon-Tyne, U.K. | lld:pubmed |
| pubmed-article:7955905 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7955905 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7955905 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7955905 | lld:pubmed |
