| pubmed-article:7949151 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7949151 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:7949151 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7949151 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:7949151 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:7949151 | lifeskim:mentions | umls-concept:C0024314 | lld:lifeskim |
| pubmed-article:7949151 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:7949151 | lifeskim:mentions | umls-concept:C0042767 | lld:lifeskim |
| pubmed-article:7949151 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7949151 | pubmed:dateCreated | 1994-12-29 | lld:pubmed |
| pubmed-article:7949151 | pubmed:abstractText | Posttransplant patients undergoing prolonged cyclosporine A (CsA) immunosuppressive therapy have been reported to have increased incidence of Epstein-Barr virus (EBV)-associated lymphoproliferative disorders. We undertook experiments to analyze the possible actions of CsA during EBV-infection of human peripheral blood mononuclear cells (PBMC). EBV-infected B cells cultured with CsA demonstrated increased EBV B-cell outgrowth as compared with those cultured without CsA. PBMC, after infection with EBV and CsA treatment, demonstrated increased interleukin-6 (IL-6) activity in the culture supernatant. The induction of IL-6 appears to differ within the various lymphocyte populations. In monocytes, IL-6 expression appears preferentially induced by EBV and is initiated by the binding of the two major virion glycoproteins, gp350 and gp220. Expression of IL-6 in T cells appears to be due mainly to CsA. B cells also express IL-6 after EBV exposure, but not after CsA treatment. EBV-immortalized B-cell lines cultured with CsA exhibited both an increased number of cells expressing viral lytic-cycle antigens and increased amounts of lytic-cycle proteins. IL-6, which is induced by CsA in PBMC, was also capable of inducing the lytic viral cycle in several EBV-immortalized cells. CsA, in promoting both increased numbers of lytic EBV B cells and an EBV paracrine factor, IL-6, within the microenvironment of EBV B cell:T cell and EBV B cell:monocyte interactions, may result in increased EBV B-cell immortalization and ultimately lead to the promotion of B-cell lymphomas in immunosuppressed patients. | lld:pubmed |
| pubmed-article:7949151 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7949151 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7949151 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7949151 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7949151 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7949151 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7949151 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7949151 | pubmed:author | pubmed-author:MenezesJJ | lld:pubmed |
| pubmed-article:7949151 | pubmed:author | pubmed-author:TannerJ EJE | lld:pubmed |
| pubmed-article:7949151 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7949151 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7949151 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:7949151 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7949151 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7949151 | pubmed:pagination | 3956-64 | lld:pubmed |
| pubmed-article:7949151 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7949151 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7949151 | pubmed:articleTitle | Interleukin-6 and Epstein-Barr virus induction by cyclosporine A: potential role in lymphoproliferative disease. | lld:pubmed |
| pubmed-article:7949151 | pubmed:affiliation | Laboratory of Immunovirology, Pediatric Research Center, University of Montréal, Quebéc, Canada. | lld:pubmed |
| pubmed-article:7949151 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7949151 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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